Scandium(III) triflate-catalyzed coumarin synthesis

Keumnyeo Jung, Yun Jeong Park, Jae Sang Ryu

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Scandium(III) triflate is an excellent catalyst in the von Pechmann condensation. The solvent-free catalytic reactions proceed smoothly with a range of phenols and β-ketoesters in the presence of 10 mol% scandium(III) triflate at 80°C. This simple method affords various 4-substituted coumarins in good to excellent yield and is superior to the classical method in several aspects: solvent-free conditions, short reaction times, a decreased catalyst loading, a mild reaction temperature, and an easy workup.

Original languageEnglish
Pages (from-to)4395-4406
Number of pages12
JournalSynthetic Communications
Issue number24
StatePublished - Jan 2008

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2006-331-E00438) and the second stage of the Brain Korea 21 Project.


  • Coumarins
  • Pechmann reaction
  • Phenols
  • Sc(OTf)
  • Solvent-free


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