Scalalactams A–D, scalarane sesterterpenes with a γ-lactam moiety from a Korean Spongia sp. Marine sponge

Inho Yang, Jusung Lee, Jihye Lee, Dongyup Hahn, Jungwook Chin, Dong Hwan Won, Jaeyoung Ko, Hyukjae Choi, Ahreum Hong, Sang Jip Nam, Heonjoong Kang

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Abstract

Intensive study on the chemical components of a Korean marine sponge, Spongia sp., has led to the isolation of four new scalarane sesterterpenes, scalalactams A–D (1–4). Their chemical structures were elucidated from the analysis of spectroscopic data including 1D-and 2D-NMR as well as MS data. Scalalactams A–D (1–4) possess a scalarane carbon skeleton with a rare structural feature of a γ-lactam moiety within the molecules. Scalalactams A and B (1 and 2) have an extended isopropanyl chain at the lactam ring, and scalalactams C and D (3 and 4) possess a phenethyl group at the lactam ring moiety. Scalalactams A–D (1–4) did not show FXR antagonistic activity nor cytotoxicity up to 100 μM.

Original languageEnglish
Article number3187
JournalMolecules
Volume23
Issue number12
DOIs
StatePublished - 3 Dec 2018

Keywords

  • Marine natural products
  • Marine sponge
  • Scalalactams
  • Scalarane sesterterpenes
  • Spongia sp

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