Sasa quelpaertensis leaf extract improves high fat diet-induced lipid abnormalities and regulation of lipid metabolism genes in rats

Jina Kim, Yoo Sun Kim, Hyun Ah Lee, Ji Ye Lim, Mina Kim, Oran Kwon, Hee Chul Ko, Se Jae Kim, Jae Ho Shin, Yuri Kim

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Sasa quelpaertensis is a bamboo leaf that is only grown on Jeju Island in South Korea. It is used as a bamboo tea that is consumed for therapeutic purposes, particularly for its anti-diabetic, diuretic, and anti-inflammatory effects. This study investigated the effect of S. quelpaertensis leaf extract (SQE) on high fat-induced lipid abnormalities and regulation of lipid metabolism-related gene expressions in rats. SQE supplementation significantly decreased the levels of plasma triglycerides, total cholesterol, and low-density lipoprotein cholesterol as well as the atherogenic index. SQE restored levels of plasma high-density lipoprotein cholesterol, which were lowered by a high fat diet. Plasma and cardiac resistin levels were also significantly decreased by SQE supplementation. In adipose tissue, mRNA levels of CAAT/enhancer-binding protein β (C/EBPβ) were suppressed in the SQE group. SQE supplementation decreased the accumulation of lipid droplets, inflammatory cell infiltrations, levels of triglycerides, and total lipids in the liver and effectively down-regulated expression of sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthetase (FAS), and uncoupling protein 2 (UCP-2). These results suggest that SQE may be a potential treatment for high fat-related disorders by improving lipid profiles and modulating lipid metabolism.

Original languageEnglish
Pages (from-to)571-581
Number of pages11
JournalJournal of Medicinal Food
Volume17
Issue number5
DOIs
StatePublished - 1 May 2014

Keywords

  • gene expression
  • high-fat diet
  • lipid metabolism
  • lipid profile
  • Sasa quelpaertensis leaf

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