Salsolinol, an endogenous neurotoxin, enhances platelet aggregation and thrombus formation

Ok Nam Bae, Young Dae Kim, Kyung Min Lim, Ji Yoon Noh, Seung Min Chung, Keunyoung Kim, Suyoung Hong, Sue Shin, Jong Hyun Yoon, Jin Ho Chung

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Salsolinol, an endogenous neurotoxin, is known to be involved in the neuropathy of Parkinson's disease and chronic alcoholism. In these diseases, increased thrombotic events are also commonly reported, yet the mechanism underlying remains poorly understood. Here we report that salsolinol can enhance agonist-induced platelet aggregation and granular secretion, which is essential in the thrombus formation. In rat and human platelets, agonist-induced platelet aggregation was significantly increased by salsolinol in a concentration- dependent manner. Agonist-induced granular secretions of serotonin and concomitant P-selectin expression were also augmented by salsolinol. α2-adrenergic blockers attenuated the salsolinol-enhanced aggregation and the inhibition of cyclic AMP generation was found, suggesting the involvement of α2-adrenergic receptor-mediated pathways in these events. In accord with the in-vitro results, in an arterial and venous thrombosis model in vivo in the rat, salsolinol shortened vessel occlusion time and increased thrombus formation, respectively. In conclusion, we demonstrated that salsolinol can enhance agonist-induced aggregation and granular secretion in platelets through α2-adrenergic receptor activation, which resulted in the increased thrombus formation in vivo. These results suggest that salsolinol-enhanced platelet aggregation could be a possible contributing factor to the thrombotic events observed in Parkinson's disease and alcoholism.

Original languageEnglish
Pages (from-to)52-59
Number of pages8
JournalThrombosis and Haemostasis
Issue number1
StatePublished - Jul 2008


  • Alcoholism
  • Parkinson's disease
  • Platelets
  • Salsolinol
  • Thrombosis


Dive into the research topics of 'Salsolinol, an endogenous neurotoxin, enhances platelet aggregation and thrombus formation'. Together they form a unique fingerprint.

Cite this