@article{621d61362f2e4fafbd078324e4154bad,
title = "Saccharoquinoline, a cytotoxic alkaloidal meroterpenoid from marine-derived bacterium Saccharomonospora sp.",
abstract = "A cytotoxic alkaloidal meroterpenoid, saccharoquinoline (1), has been isolated from the fermentation broth of the marine-derived bacterium Saccharomonospora sp. CNQ-490. The planar structure of 1 was elucidated by 1D, 2D NMR, and MS spectroscopic data analyzes, while the relative configuration of 1 was defined through the interpretation of NOE spectroscopic data. Saccharoquinoline (1) is composed of a drimane-type sesquiterpene unit in combination with an apparent 6,7,8-trihydroxyquinoline-2-carboxylic acid. This combination of biosynthetic pathways was observed for the first time in natural microbial products. Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition.",
keywords = "Cytotoxicity, Marine natural product, Meroterpenoid, Saccharomonospora sp",
author = "Le, {Tu Cam} and Lee, {Eun Ju} and Jihye Lee and Ahreum Hong and Yim, {Chae Yoon} and Inho Yang and Hyukjae Choi and Jungwook Chin and Cho, {Sung Jin} and Jaeyoung Ko and Hayoung Hwang and Nam, {Sang Jip} and William Fenical",
note = "Funding Information: Funding: The present study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning under grant NRF-2017R1D1A1B03028172 (to S.-J.N.), and by the US National Cancer Institute (NIH) under grant R37 CA044848 (to W.F.). Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",
year = "2019",
month = feb,
day = "2",
doi = "10.3390/md17020098",
language = "English",
volume = "17",
journal = "Marine Drugs",
issn = "1660-3397",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",
}