@article{9e5ecc41b3a34a34803402a9906a46cc,
title = "Saccharomonopyrones A–C, new α-pyrones from a marine sediment-derived bacterium Saccharomonospora sp. CNQ-490",
abstract = "Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A–C (1–3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first α-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted α-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC50 value of 140 µM.",
keywords = "Marine natural products, Saccharomonospora sp., α-pyrones",
author = "Yim, {Chae Yoon} and Le, {Tu Cam} and Lee, {Tae Gu} and Inho Yang and Hansol Choi and Jusung Lee and Kang, {Kyung Yun} and Lee, {Jin Sil} and Lim, {Kyung Min} and Yee, {Sung Tae} and Heonjoong Kang and Nam, {Sang Jip} and William Fenical",
note = "Funding Information: Acknowledgments: This work was supported by the Marine Biotechnology Program, the Ministry of Oceans and Fisheries, Korea and by the National Research Foundation of Korea grants (NRF-2012M1A5A1054307), the Ministry of Education, Science and Technology, Korea., by Suncheon Research Center for Natural Medicines (to SJN), and by the US National Cancer Institute (NIH) under grant R37 CA044848 (to WF). Publisher Copyright: {\textcopyright} 2017 by the authors. Licensee MDPI.",
year = "2017",
month = aug,
doi = "10.3390/md15080239",
language = "English",
volume = "15",
journal = "Marine Drugs",
issn = "1660-3397",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "8",
}