Saccharomonopyrones A–C, new α-pyrones from a marine sediment-derived bacterium Saccharomonospora sp. CNQ-490

Chae Yoon Yim, Tu Cam Le, Tae Gu Lee, Inho Yang, Hansol Choi, Jusung Lee, Kyung Yun Kang, Jin Sil Lee, Kyung Min Lim, Sung Tae Yee, Heonjoong Kang, Sang Jip Nam, William Fenical

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18 Scopus citations

Abstract

Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A–C (1–3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first α-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted α-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC50 value of 140 µM.

Original languageEnglish
Article number239
JournalMarine Drugs
Volume15
Issue number8
DOIs
StatePublished - Aug 2017

Keywords

  • Marine natural products
  • Saccharomonospora sp.
  • α-pyrones

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