Saccharobisindole, neoasterric methyl ester, and 7‐chloro‐4(1h)‐quinolone: Three new compounds isolated from the marine bacterium saccharomonospora sp.

Sohee Kim; Tu Cam Le; Sang Ah Han; Prima F. Hillman; Ahreum Hong; Sunghoon Hwang; Young Eun Du; Hiyoung Kim; Dong Chan Oh; Sun Shin Cha; Jihye Lee; Sang Jip Nam; William Fenical

doi:10.3390/md20010035

Saccharobisindole, neoasterric methyl ester, and 7‐chloro‐4(1h)‐quinolone: Three new compounds isolated from the marine bacterium saccharomonospora sp.

Sohee Kim
, Tu Cam Le
, Sang Ah Han
, Prima F. Hillman
, Ahreum Hong
, Sunghoon Hwang
, Young Eun Du
, Hiyoung Kim
, Dong Chan Oh
, Sun Shin Cha
, Jihye Lee
, Sang Jip Nam
, William Fenical

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ‐490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7‐chloro‐4(1H)‐quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high‐resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti‐quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560.

Original language	English
Article number	35
Journal	Marine Drugs
Volume	20
Issue number	1
DOIs	https://doi.org/10.3390/md20010035
State	Published - Jan 2022

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Antibacterial activity
Marine natural products
Saccharomonospora sp

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10.3390/md20010035

Cite this

Kim, S., Le, T. C., Han, S. A., Hillman, P. F., Hong, A., Hwang, S., Du, Y. E., Kim, H., Oh, D. C., Cha, S. S., Lee, J., Nam, S. J., & Fenical, W. (2022). Saccharobisindole, neoasterric methyl ester, and 7‐chloro‐4(1h)‐quinolone: Three new compounds isolated from the marine bacterium saccharomonospora sp. Marine Drugs, 20(1), Article 35. https://doi.org/10.3390/md20010035

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title = "Saccharobisindole, neoasterric methyl ester, and 7‐chloro‐4(1h)‐quinolone: Three new compounds isolated from the marine bacterium saccharomonospora sp.",

abstract = "Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ‐490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7‐chloro‐4(1H)‐quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high‐resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti‐quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560.",

keywords = "Antibacterial activity, Marine natural products, Saccharomonospora sp",

author = "Sohee Kim and Le, \{Tu Cam\} and Han, \{Sang Ah\} and Hillman, \{Prima F.\} and Ahreum Hong and Sunghoon Hwang and Du, \{Young Eun\} and Hiyoung Kim and Oh, \{Dong Chan\} and Cha, \{Sun Shin\} and Jihye Lee and Nam, \{Sang Jip\} and William Fenical",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jan,

doi = "10.3390/md20010035",

language = "English",

volume = "20",

journal = "Marine Drugs",

issn = "1660-3397",

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TY - JOUR

T1 - Saccharobisindole, neoasterric methyl ester, and 7‐chloro‐4(1h)‐quinolone

T2 - Three new compounds isolated from the marine bacterium saccharomonospora sp.

AU - Kim, Sohee

AU - Le, Tu Cam

AU - Han, Sang Ah

AU - Hillman, Prima F.

AU - Hong, Ahreum

AU - Hwang, Sunghoon

AU - Du, Young Eun

AU - Kim, Hiyoung

AU - Oh, Dong Chan

AU - Cha, Sun Shin

AU - Lee, Jihye

AU - Nam, Sang Jip

AU - Fenical, William

PY - 2022/1

Y1 - 2022/1

N2 - Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ‐490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7‐chloro‐4(1H)‐quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high‐resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti‐quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560.

AB - Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ‐490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7‐chloro‐4(1H)‐quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high‐resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti‐quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560.

KW - Antibacterial activity

KW - Marine natural products

KW - Saccharomonospora sp

UR - https://www.scopus.com/pages/publications/85121995406

U2 - 10.3390/md20010035

DO - 10.3390/md20010035

M3 - Article

C2 - 35049890

AN - SCOPUS:85121995406

SN - 1660-3397

VL - 20

JO - Marine Drugs

JF - Marine Drugs

IS - 1

M1 - 35

ER -

Saccharobisindole, neoasterric methyl ester, and 7‐chloro‐4(1h)‐quinolone: Three new compounds isolated from the marine bacterium saccharomonospora sp.

Abstract

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Keywords

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