Saccharobisindole, neoasterric methyl ester, and 7‐chloro‐4(1h)‐quinolone: Three new compounds isolated from the marine bacterium saccharomonospora sp.

Sohee Kim, Tu Cam Le, Sang Ah Han, Prima F. Hillman, Ahreum Hong, Sunghoon Hwang, Young Eun Du, Hiyoung Kim, Dong Chan Oh, Sun Shin Cha, Jihye Lee, Sang Jip Nam, William Fenical

Research output: Contribution to journalArticlepeer-review

Abstract

Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ‐490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7‐chloro‐4(1H)‐quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high‐resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti‐quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560.

Original languageEnglish
Article number35
JournalMarine Drugs
Volume20
Issue number1
DOIs
StatePublished - Jan 2022

Keywords

  • Antibacterial activity
  • Marine natural products
  • Saccharomonospora sp

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