Abstract
Analysis of the chemical components from the culture broth of the marine bacterium Saccharomonospora sp. CNQ‐490 has yielded three novel compounds: saccharobisindole (1), neoasterric methyl ester (2), and 7‐chloro‐4(1H)‐quinolone (3), in addition to acremonidine E (4), pinselin (5), penicitrinon A (6), and penicitrinon E (7). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high‐resolution mass spectrometry (HRMS) data. Compound 2 generated weak inhibition activity against Bacillus subtilis KCTC2441 and Staphylococcus aureus KCTC1927 at concentrations of 32 μg/mL and 64 μg/mL, respectively, whereas compounds 1 and 3 did not have any observable effects. In addition, compound 2 displayed weak anti‐quorum sensing (QS) effects against S. aureus KCTC1927 and Micrococcus luteus SCO560.
Original language | English |
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Article number | 35 |
Journal | Marine Drugs |
Volume | 20 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2022 |
Bibliographical note
Funding Information:Funding: This research was supported by National Research Foundation of Korea Grants funded by the Korean Government (Ministry of Science and ICT; 2021R1A4A2001251 to S.‐J.N.), in part by the Korea Polar Research Institute Grant PM21030 (15250103 to S.‐S.C.) and funded by the Ministry of Oceans and Fisheries, Korea grant numbers and in part by the U.S. NIH National Cancer Institute under grant R37 CA044848 to W.F.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
- Antibacterial activity
- Marine natural products
- Saccharomonospora sp