Rosacea and its association with enteral microbiota in Korean females

Jae Hui Nam, Yeojun Yun, Han Saem Kim, Han Na Kim, Ho Joo Jung, Yoosoo Chang, Seungho Ryu, Hocheol Shin, Hyung Lae Kim, Won Serk Kim

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Rosacea is a chronic inflammatory dermatosis affecting the face and eyes. An association between systemic comorbidities and rosacea has been reported, but the link to enteral microbiota is uncertain. We aimed to investigate the link between rosacea and enteral microbiota. A cross-sectional study was performed in a sample of Korean women who participated in a health check-up programme at the Kangbuk Samsung Hospital Health Screening Center between 23 June 2014 and 5 September 2014. The gut microbiome was evaluated by 16S rRNA gene and metagenome sequence analyses. A total of 12 rosacea patients and 251 controls were enrolled. We identified links between rosacea and several changes in gut microbiota: reduced abundance of Peptococcaceae family unknown genus, Methanobrevibacter (genus), Slackia (genus), Coprobacillus (genus), Citrobacter (genus), and Desulfovibrio (genus), and increased abundance of Acidaminococcus (genus), Megasphaera (genus), and Lactobacillales order unknown family unknown genus. A link between rosacea and enteral microbiota was observed in this metagenomic study. A large and elaborate study is needed to confirm these findings and to elucidate the mechanisms involved.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalExperimental Dermatology
Issue number1
StatePublished - Jan 2018


  • gut microbiota
  • metagenome
  • rosacea


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