Role of the lateral mammillary nucleus in the rat head direction circuit: A combined single unit recording and lesion study

Hugh T. Blair; Jeiwon Cho; Patricia E. Sharp

doi:10.1016/S0896-6273(00)80657-1

Role of the lateral mammillary nucleus in the rat head direction circuit: A combined single unit recording and lesion study

Hugh T. Blair, Jeiwon Cho, Patricia E. Sharp

Brain & Cognitive Sciences

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

We recorded head direction (HD) cells from the lateral mammillary nucleus (LMN) and anterior thalamus (ATN) of freely behaving rats and also made bilateral lesions of LMN while recording HD cells from ATN. We discovered that the tuning functions of LMN HD cells become narrower during contraversive head turns, but not ipsiversive head turns, compared to when the head is not turning. This narrowing effect does not occur for ATN HD cells. We also found that the HD signal in LMN leads that in ATN by about 15- 20 ms. When LMN was lesioned bilaterally, HD cells in ATN immediately lost their directional firing properties and never recovered them. Based on these findings, we argue that LMN may be an essential component of an attractor- integrator network that participates in generating the HD signal.

Original language	English
Pages (from-to)	1387-1397
Number of pages	11
Journal	Neuron
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/S0896-6273(00)80657-1
State	Published - Dec 1998

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title = "Role of the lateral mammillary nucleus in the rat head direction circuit: A combined single unit recording and lesion study",

abstract = "We recorded head direction (HD) cells from the lateral mammillary nucleus (LMN) and anterior thalamus (ATN) of freely behaving rats and also made bilateral lesions of LMN while recording HD cells from ATN. We discovered that the tuning functions of LMN HD cells become narrower during contraversive head turns, but not ipsiversive head turns, compared to when the head is not turning. This narrowing effect does not occur for ATN HD cells. We also found that the HD signal in LMN leads that in ATN by about 15- 20 ms. When LMN was lesioned bilaterally, HD cells in ATN immediately lost their directional firing properties and never recovered them. Based on these findings, we argue that LMN may be an essential component of an attractor- integrator network that participates in generating the HD signal.",

author = "Blair, {Hugh T.} and Jeiwon Cho and Sharp, {Patricia E.}",

note = "Funding Information: This work was supported by NIMH NRSA Fellowship 1 F31 MH11102–01A1 to H. T. B. and by NIH grant R01 NS35191–01A1 to P. E. S. ",

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AU - Blair, Hugh T.

AU - Cho, Jeiwon

AU - Sharp, Patricia E.

N1 - Funding Information: This work was supported by NIMH NRSA Fellowship 1 F31 MH11102–01A1 to H. T. B. and by NIH grant R01 NS35191–01A1 to P. E. S.

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N2 - We recorded head direction (HD) cells from the lateral mammillary nucleus (LMN) and anterior thalamus (ATN) of freely behaving rats and also made bilateral lesions of LMN while recording HD cells from ATN. We discovered that the tuning functions of LMN HD cells become narrower during contraversive head turns, but not ipsiversive head turns, compared to when the head is not turning. This narrowing effect does not occur for ATN HD cells. We also found that the HD signal in LMN leads that in ATN by about 15- 20 ms. When LMN was lesioned bilaterally, HD cells in ATN immediately lost their directional firing properties and never recovered them. Based on these findings, we argue that LMN may be an essential component of an attractor- integrator network that participates in generating the HD signal.

AB - We recorded head direction (HD) cells from the lateral mammillary nucleus (LMN) and anterior thalamus (ATN) of freely behaving rats and also made bilateral lesions of LMN while recording HD cells from ATN. We discovered that the tuning functions of LMN HD cells become narrower during contraversive head turns, but not ipsiversive head turns, compared to when the head is not turning. This narrowing effect does not occur for ATN HD cells. We also found that the HD signal in LMN leads that in ATN by about 15- 20 ms. When LMN was lesioned bilaterally, HD cells in ATN immediately lost their directional firing properties and never recovered them. Based on these findings, we argue that LMN may be an essential component of an attractor- integrator network that participates in generating the HD signal.

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Role of the lateral mammillary nucleus in the rat head direction circuit: A combined single unit recording and lesion study

Abstract

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