Role of IN-1233 in the prevention of neointimal hyperplasia after stent placement in a rat artery model

Hyun Jung Yoon, Ho Young Song, Jin Hyoung Kim, Kang Sun Hong, Yeon Joo Kim, Hyung Gyu Park, Dae Kee Kim

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6 Scopus citations


Purpose: To evaluate the efficacy of an activin receptorlike kinase (ALK) 5 inhibitor, IN-1233, for the prevention of neointimal hyperplasia after bare stent placement in a rat common iliac artery (CIA) model. Materials and Methods: All experiments were approved by the committee of animal research. A self-expanding metallic bare stent (2 mm × 6 mm) was inserted into the left CIA of 26 Sprague-Dawley male rats (300360 g) under fluoroscopic guidance. IN-1233 was injected via the intraperitoneal route daily in 13 rats for 8 weeks after stent placement (group A); the other 13 rats underwent stent placement only (group B). Angiography was performed immediately and 4 weeks and 8 weeks after stent placement. Rats were sacrificed at 8 weeks after stent placement, and histologic findings were obtained. The neointimal area (NA), percentage of neointimal hyperplasia (%NH), and neointimal-to-medial area ratio (N/M) were assessed and compared between the two groups. Results: Stent placement was technically successful. In 25 rats, arteries with stent placement were angiographically patent, whereas 1 rat in group B had an occlusion. The NA (0.31 mm 2 ± 0.09 vs 0.56 mm 2 ± 0.17; P <.001), the %NH (26.16% ± 8.75 vs 44.71% ± 17.75; P <.001) and the N/M (1.93 ± 0.77 vs 4.77 ± 2.26; P <.001) were significantly decreased in group A compared with group B. Conclusions: IN-1233 was shown in this study to be effective for the prevention of neointimal hyperplasia after bare metallic stent placement in a rat CIA model.

Original languageEnglish
Pages (from-to)1321-1328
Number of pages8
JournalJournal of Vascular and Interventional Radiology
Issue number9
StatePublished - Sep 2011

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare and Family Affairs , Republic of Korea, ( A-080773 ). None of the authors have identified a conflict of interest.


  • %NH
  • ALK
  • CIA
  • EEL
  • IEL
  • LA
  • MA
  • N/M
  • NA
  • TGF-β
  • activin receptorlike kinase
  • common iliac artery
  • external elastic lamina
  • internal elastic lamina
  • luminal area
  • medial area
  • neointimal area
  • neointimal-to-medial area ratio
  • percentage of neointimal hyperplasia
  • transforming growth factor-β


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