Role of FDG-PET/CT in detecting lymphomatous bone marrow involvement in patients with newly diagnosed diffuse large B-cell lymphoma

Junshik Hong, Yukyung Lee, Yeonjeong Park, Seog Gyun Kim, Kyung Hoon Hwang, Soon Ho Park, Jihoon Jeong, Kyung Hee Kim, Jeong Yeal Ahn, Sanghui Park, Jinny Park, Jae Hoon Lee

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations

Abstract

To evaluate the role of FDG-PET/CT in detecting bone marrow (BM) involvement, pre-treatment bilateral bone marrow biopsies (BMBs) and FDG-PET/CT scans of 89 patients with diffuse large B-cell lymphoma (DLBCL) treated with rituximab-CHOP were reviewed and analyzed. Fourteen patients (15.7%) had lymphomatous involvement based on BMB (BMB+), and 17 patients (19.1%) had the possibility of BM involvement on FDG-PET/CT (FDG-PET/CT+). Seventy-two patients (80.8%) had concordant results between BMB and FDG-PET/CT (seven patients were positive for both, and 65 patients were negative for both), but 17 patients (19.2%) had a discordant interpretation (seven patients were BMB+ and FDG-PET/CT-, and ten were BMB- and FDG-PET/CT+). Although BMB+ patients had an inferior 2-year EFS (37.0% vs. 79.8%, p<0.001) and OS (36.3% vs. 81.0%, p<0.001) compared to BMB- patients, no differences in EFS (62.6% vs. 72.7%, p=0.185) and OS (59.4% vs. 78.0%, p=0.146) were shown between FDG-PET/CT+ and FDG-PET/CT- patients. Whereas six of seven patients with diffuse hypermetabolism were BMB+, only one of ten patients with focal hypermetabolism was BMB+. The results suggest that FDG-PET/CT had a limited value to detect BM involvement in patients with DLBCL. Focal hypermetabolism of hematopoietic BM in FDG-PET/ CT had no impact on survival.

Original languageEnglish
Pages (from-to)687-695
Number of pages9
JournalAnnals of Hematology
Volume91
Issue number5
DOIs
StatePublished - May 2012

Keywords

  • Bone marrow
  • Diffuse large B-cell lymphoma
  • FDG-PET/CT
  • Lymphoma

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