Role of Adjuvant Treatment in High-risk Patients Following Resection for Gallbladder Cancer

Younghee Park, Kiryun Kim, Hae Jin Park, Ha Jung Chun, Dongho Choi, Kyubo Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: To identify prognostic factors for surgically resected gallbladder cancer (GBC). Patients and Methods: Medical records of 66 patients with GBC undergoing potentially curative resection between 2001 and 2017 were retrospectively reviewed. Results: After a median follow-up of 39.9 months (range=0.5-216.4 months), 22 locoregional recurrences and 25 distant metastases occurred. Adjuvant radiotherapy and adjuvant chemotherapy failed to prove efficacy in all patient groups. In patients with stage III-IV GBC, adjuvant chemotherapy showed a marginally positive effect on locoregional control (p=0.064), and was significantly beneficial for overall survival (p=0.040), and adjuvant treatment improved both locoregional control and overall survival (p=0.029 and p=0.005, respectively). On multivariate analysis, a negative resection margin was a significant prognostic factor for superior local control, and disease-free and overall survival (p=0.003, p=0.010 and p=0.005, respectively) and adjuvant treatment was associated with improved overall survival (p=0.018). Conclusion: Adjuvant treatment is recommended for patients with stage III-IV GBC following curative surgical resection.

Original languageEnglish
Pages (from-to)961-968
Number of pages8
JournalIn Vivo
Volume36
Issue number2
DOIs
StatePublished - Mar 2022

Keywords

  • Gallbladder cancer
  • adjuvant chemotherapy
  • adjuvant radiotherapy
  • adjuvant treatment
  • prognostic factor

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