TY - JOUR
T1 - Risk of Pregnancy Complications and Low Birth Weight Offsprings in Korean Women With Rheumatic Diseases
T2 - A Nationwide Population-Based Study
AU - Park, Jin Su
AU - Chung, Min Kyung
AU - Lim, Hyunsun
AU - Lee, Jisoo
AU - Lee, Chan Hee
N1 - Funding Information:
This work was supported by the National Health Insurance Ilsan Hospital grant (2018-20-002). This study used data from the NHIS-National Health Information Database (NHIS-2020-1-407), created by the NHIS. The authors alone are responsible for the content and writing of the paper.
Publisher Copyright:
© 2022 The Korean Academy of Medical Sciences. All Rights Reserved.
PY - 2022/1
Y1 - 2022/1
N2 - Background: To determine the risk of pregnancy complications and adverse offspring outcomes in Korean women with rheumatic diseases (RDs). Methods: Women aged 20-44 years with pregnancies ending in delivery were identified from the National Health Insurance Service-National Health Information Database (2009-2016). Women with RD including systemic lupus erythematosus (SLE), seropositive rheumatoid arthritis (SPRA), and ankylosing spondylitis (AS) (n = 4,284) were age-matched with controls (n = 26,023). Outcome variables included threatened abortion (TA), preterm birth (PB), preeclampsia/eclampsia (PE/E), intrauterine growth retardation (IGR), urinary tract infection, low birth weight (LBW) offsprings, and offspring death within 1 year of birth. Results: Women with RDs had increased risks for cesarean section delivery (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.4-1.6), TA (OR, 1.4; 95% CI, 1.2-1.5), PB (OR, 2.4; 95% CI, 1.9-3.2), PE/E (OR, 4.4; 95% CI, 3.3-5.9), and IGR (OR, 2.4; 95% CI, 2.0-3.1) than the controls. The risk of pregnancy complications was increased in SLE and SPRA pregnancies but not in AS pregnancies. Offsprings of women with RDs had an increased risk of LBW (OR, 4.0; 95% CI, 3.2-4.9). The offspring mortality rate within 1 year of birth was higher in women with RDs (6.2/10,000 persons) than in the controls (4.9/10,000 persons). Conclusion: Women with RDs are at a risk of developing pregnancy complications, and the risk of LBW offsprings and offspring death within 1 year of birth is increased in these women. Therefore, this population requires special attention during their childbearing years.
AB - Background: To determine the risk of pregnancy complications and adverse offspring outcomes in Korean women with rheumatic diseases (RDs). Methods: Women aged 20-44 years with pregnancies ending in delivery were identified from the National Health Insurance Service-National Health Information Database (2009-2016). Women with RD including systemic lupus erythematosus (SLE), seropositive rheumatoid arthritis (SPRA), and ankylosing spondylitis (AS) (n = 4,284) were age-matched with controls (n = 26,023). Outcome variables included threatened abortion (TA), preterm birth (PB), preeclampsia/eclampsia (PE/E), intrauterine growth retardation (IGR), urinary tract infection, low birth weight (LBW) offsprings, and offspring death within 1 year of birth. Results: Women with RDs had increased risks for cesarean section delivery (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.4-1.6), TA (OR, 1.4; 95% CI, 1.2-1.5), PB (OR, 2.4; 95% CI, 1.9-3.2), PE/E (OR, 4.4; 95% CI, 3.3-5.9), and IGR (OR, 2.4; 95% CI, 2.0-3.1) than the controls. The risk of pregnancy complications was increased in SLE and SPRA pregnancies but not in AS pregnancies. Offsprings of women with RDs had an increased risk of LBW (OR, 4.0; 95% CI, 3.2-4.9). The offspring mortality rate within 1 year of birth was higher in women with RDs (6.2/10,000 persons) than in the controls (4.9/10,000 persons). Conclusion: Women with RDs are at a risk of developing pregnancy complications, and the risk of LBW offsprings and offspring death within 1 year of birth is increased in these women. Therefore, this population requires special attention during their childbearing years.
KW - Ankylosing Spondylitis
KW - Health Services Research
KW - Pregnancy
KW - Rheumatoid Arthritis
KW - Systemic Lupus Erythematosus
UR - http://www.scopus.com/inward/record.url?scp=85123462068&partnerID=8YFLogxK
U2 - 10.3346/JKMS.2022.37.E18
DO - 10.3346/JKMS.2022.37.E18
M3 - Article
C2 - 35014229
AN - SCOPUS:85123462068
SN - 1011-8934
VL - 37
SP - 1
EP - 11
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
IS - 2
M1 - e18
ER -