Risk of Advanced Colorectal Neoplasia According to the Number of High-Risk Findings at Index Colonoscopy: A Korean Association for the Study of Intestinal Disease (KASID) Study

Yoon Suk Jung, Dong Il Park, Won Hee Kim, Chang Soo Eun, Soo Kyung Park, Bong Min Ko, Geom Seog Seo, Jae Myung Cha, Jae Jun Park, Kyeong Ok Kim, Chang Mo Moon, Yunho Jung, Eun Soo Kim, Seong Ran Jeon, Chang Kyun Lee

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Data regarding outcomes for patients with multiple findings for high-risk adenomas are scarce. Aim: To compare the risk for colorectal neoplasm (CRN) recurrence according to the number of high-risk findings. Methods: This was a retrospective and multicenter study. Patients who had one or more high-risk adenomas at the index colonoscopy and underwent follow-up colonoscopy 2.5 or more years after the index colonoscopy were included. The number of high-risk findings was defined as follows: number of adenomas larger than 1 cm + number of adenomas with HGD + number of adenomas with a villous component + existence (counted as 1) or nonexistence (counted as 0) of three or more adenomas. Results: A total of 1646 patients were included, and the mean duration between index and follow-up colonoscopy was approximately 4 years. The cumulative incidence rate of recurrent advanced CRN in patients with three or more high-risk findings was higher than that in patients with one or two high-risk findings (p < 0.001). However, the difference in 3-year cumulative incidence rates of recurrent advanced CRN between the two groups was not great, although it was statistically significant (4.8 vs. 2.3 %, p = 0.039). Conclusions: A 3-year surveillance interval for patients with multiple high-risk findings, regardless of the number of high-risk findings, appears reasonable.

Original languageEnglish
Pages (from-to)1661-1668
Number of pages8
JournalDigestive Diseases and Sciences
Volume61
Issue number6
DOIs
StatePublished - 1 Jun 2016

Keywords

  • Colonoscopy
  • Colorectal neoplasia
  • High-risk adenoma
  • Recurrence

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