Risk Factors of Vasopressor-Induced Symmetrical Peripheral Gangrene

Jung Woo Kwon, Min Ki Hong, Bo Young Park

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background Symmetrical peripheral gangrene (SPG) is an uncommon syndrome showing symmetrical gangrene in acral regions without evidence of large-vessel occlusion or vasculitis. Intravenous vasopressors are frequently used to manage hemodynamically unstable patients. There have been few reports about SPG after using inotropics. However, risk factors for SPG have not been extensively studied. Therefore, the objective of this study was to analyze several cases of SPG and identify risk factors for SPG. Methods From October 2013 to October 2016, 36 patients with SPG after using vasopressors were included in this study. SPG is an extremely rare disease entity. Therefore, this work was designed as a matched case-control study. For the control group, 42 patients (25 men and 17 women) with similar age, admission department, sex, and vasopressor usage in intensive care unit patients during the same period were selected. Retrospective chart review was performed to identify risk factors within the following categories: medical conditions, vasopressor-related factors, and Sequential Organ Failure Assessment scores. Results Differences between the 2 groups concerning medical condition-related variables did not exist. Statistically significant differences were found in intensive care unit duration (P = 0.0011) and survival. All vasopressor-related factors were adjusted according to weights of patients. Weight-compensated mean dose of dopamin significantly (P = 0.028) affected the occurrence of SPG. Weight-compensated peak dose of norpin, dopamin, and epinephrine also significantly contributed to SPG. Conclusions Symmetrical peripheral gangrene is a rare clinical syndrome related with a high mortality and up to 70% of patients who survive require amputation. Several studies have mentioned that there are several factors affecting the result of SPG. Few studies on SPG have been reported and most of them are case reports. In this study, we revealed the influence of vasopressors to the occurrence of SPG, and this was the first matched case-control study based on the analysis of multiple risk factors.

Original languageEnglish
Pages (from-to)622-627
Number of pages6
JournalAnnals of Plastic Surgery
Issue number6
StatePublished - 1 Jun 2018

Bibliographical note

Funding Information:
Received June 19, 2017, and accepted for publication, after revision October 24, 2017. From the *Elle Plastic Surgery Clinic, GangNam Gu; and †Department of Plastic and Reconstructive Surgery, Ewha Womans University, Mokdong Hospital, Yangcheon-Gu, Seoul, South Korea. Conflicts of interest and sources of funding: This work was supported by the Ewha Womans University Research Grant of 2015. Reprints: Bo Young Park, MD, PhD, Department of Plastic and Reconstructive Surgery, Ewha Womans University, Mokdong Hospital, Mok 5-dong, Yangcheon-Gu, Seoul 158-710, South Korea. E-mail: byps@icould.com. Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. ISSN: 0148-7043/18/8006–0622 DOI: 10.1097/SAP.0000000000001314

Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc. All rights reserved.


  • gangrene
  • risk factors
  • vasopressor agents


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