Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009

Seong Joon Kim, Jong Hyun Kim, Jin Han Kang, Dong Soo Kim, Ki Hwan Kim, Kyung Hyo Kim, Young Hoon Kim, Ju Young Chung, Joong Hyun Bin, Da Eun Jung, Ji Hong Kim, Hwang Min Kim, Doo Sung Cheon, Byung Hak Kang, Soon Young Seo, Byung Min Choi, Eun Hwa Choi, Jae Yoon Kim, Jung Yeun Hong, Sung Hee OhSung Ho Cha, Yae Jean Kim

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


In 2009, the first outbreak of hand, foot and mouth disease (HFMD) or herpangina (HP) caused by enterovirus 71 occurred in the Republic of Korea. This study inquired into risk factors associated with complications of HFMD or HP. A retrospective medical records review was conducted on HFMD or HP patients for whom etiologic viruses had been verified in 2009. One hundred sixty-eight patients were examined for this investigation. Eighty patients were without complications while 88 were accompanied by complications, and 2 had expired. Enterovirus 71 subgenotype C4a was the most prevalent in number with 67 cases (54.9%). In the univariate analysis, the disease patterns of HFMD rather than HP, fever longer than 4 days, peak body temperature over 39°C, vomiting, headache, neurologic signs, serum glucose over 100 mg/dL, and having an enterovirus 71 as a causative virus were significant risk factors of the complications. After multiple logistic analysis, headache (Odds ratio [OR], 10.75; P < 0.001) and neurologic signs (OR, 42.76; P < 0.001) were found to be the most significant factors. Early detection and proper management of patients with aforementioned risk factors would be necessary in order to attain a better clinical outcome.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalJournal of Korean Medical Science
Issue number1
StatePublished - 2013


  • Coxsackievirus
  • Enterovirus A, human
  • Hand, foot and mouth disease
  • Herpangina
  • Risk factors


Dive into the research topics of 'Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009'. Together they form a unique fingerprint.

Cite this