Risk Factors and Outcomes of Choroidal Neovascularization Secondary to Central Serous Chorioretinopathy

Ga In Lee, A. Young Kim, Se Woong Kang, Soo Chang Cho, Kyu Hyung Park, Sang Jin Kim, Kyung Tae Kim

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We identified clinical characteristics and risk factors of choroidal neovascularization (CNV) in eyes with prior episode of central serous chorioretinopathy (CSC). This retrospective case-control study included those initially diagnosed with CSC and developed CNV secondarily (Group 1, n = 16), those diagnosed with CNV in eyes of previous putative CSC (Group 2, n = 14), and those initially diagnosed with CSC, and did not develop CNV secondarily, as a control group for Group 1 (Group 3, n = 250). Clinical characteristics including treatment outcomes were assessed. Demographics and multimodal imaging at the time of CSC diagnosis of secondary CNV were compared between the groups to identify risk factors. Duration from diagnosis of CSC to development of CNV in Group 1 was 40.2 ± 42.0 months. Classic CNV was noted in 23 (76.7%) eyes. After treatment with intravitreal antiangiogenics with average of 4.9 times, visual acuity improved in Group 1 and Group 2 (p = 0.002). Multivariate analysis revealed that systemic hypertension, pigmentary changes, and double layer sign were associated with development of CNV secondary to CSC (p < 0.05). Hypertension, pigmentary changes, and double layer sign were independent risk factors for CNV secondary to CSC. The CNV’s responded well to treatment, resulting in improved vision.

Original languageEnglish
Article number3927
JournalScientific Reports
Volume9
Issue number1
DOIs
StatePublished - 1 Dec 2019

Bibliographical note

Publisher Copyright:
© 2019, The Author(s).

Fingerprint

Dive into the research topics of 'Risk Factors and Outcomes of Choroidal Neovascularization Secondary to Central Serous Chorioretinopathy'. Together they form a unique fingerprint.

Cite this