TY - JOUR
T1 - Risk factor control and cardiovascular events in patients with type 2 diabetes mellitus
AU - Song, Do Kyeong
AU - Hong, Young Sun
AU - Sung, Yeon Ah
AU - Lee, Hyejin
N1 - Publisher Copyright:
© 2024 Song et al.
PY - 2024/2
Y1 - 2024/2
N2 - Since patients with type 2 diabetes mellitus (T2DM) have an increased risk of cardiovascular events, interventions addressing risk factors reduce the incidence of cardiovascular disease (CVD) events. This study aimed to evaluate the difference in the incidence of CVD events according to risk factor control in patients with diabetes with and without cardio-renal disease. Methods We analyzed 113,909 patients with diabetes and 290,339 without diabetes using data released by the National Health Insurance Service (NHIS). Results Among patients with diabetes with four or five poorly controlled risk factors, hazard ratio for CVD events was 1.19 (95% confidence interval [CI], 1.06–1.34) in patients with cardio-renal disease and 2.31 (95% CI, 1.95–2.74) in patients without cardio-renal disease compared to patients with diabetes without risk factors. In subjects with diabetes and cardio-renal disease, patients with four or five poorly controlled risk factors had a higher risk of CVD mortality compared to subjects without risk factors (hazard ratio, 1.64; 95% CI, 1.18–2.30). Conclusion Controlling cardiovascular risk factors reduced the incidence of CVD events in patients with diabetes, especially those without cardio-renal disease. The degree of risk control was strongly associated with CVD mortality in patients with diabetes with baseline cardio-renal disease.
AB - Since patients with type 2 diabetes mellitus (T2DM) have an increased risk of cardiovascular events, interventions addressing risk factors reduce the incidence of cardiovascular disease (CVD) events. This study aimed to evaluate the difference in the incidence of CVD events according to risk factor control in patients with diabetes with and without cardio-renal disease. Methods We analyzed 113,909 patients with diabetes and 290,339 without diabetes using data released by the National Health Insurance Service (NHIS). Results Among patients with diabetes with four or five poorly controlled risk factors, hazard ratio for CVD events was 1.19 (95% confidence interval [CI], 1.06–1.34) in patients with cardio-renal disease and 2.31 (95% CI, 1.95–2.74) in patients without cardio-renal disease compared to patients with diabetes without risk factors. In subjects with diabetes and cardio-renal disease, patients with four or five poorly controlled risk factors had a higher risk of CVD mortality compared to subjects without risk factors (hazard ratio, 1.64; 95% CI, 1.18–2.30). Conclusion Controlling cardiovascular risk factors reduced the incidence of CVD events in patients with diabetes, especially those without cardio-renal disease. The degree of risk control was strongly associated with CVD mortality in patients with diabetes with baseline cardio-renal disease.
UR - http://www.scopus.com/inward/record.url?scp=85186307304&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0299035
DO - 10.1371/journal.pone.0299035
M3 - Article
C2 - 38422102
AN - SCOPUS:85186307304
SN - 1932-6203
VL - 19
JO - PLoS ONE
JF - PLoS ONE
IS - 2 February
M1 - e0299035
ER -