Rhodamine hydrazone derivatives as Hg2+ selective fluorescent and colorimetric chemosensors and their applications to bioimaging and microfluidic system

Ha Na Kim, Seong Won Nam, K. M.K. Swamy, Yan Jin, Xiaoqiang Chen, Yonugmee Kim, Sung Jin Kim, Sungsu Park, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

In this paper, we report new rhodamine hydrazone derivatives bearing thiol and carboxylic acid groups as selective fluorescent and colorimetric chemosensors for Hg2+. The ring-opening process of spirolactam enables the large fluorescent enhancement and colorimetric change upon the addition of Hg2+. The sample containing Hg2+ was mixed with one of the chemosensors in a microchannel where the sensor was examined using confocal laser scanning microscopy. A plot of the fluorescent intensities of both chemosensors versus the log concentration of Hg2+ exhibited a linear response (r2 = 0.95) in the range of 1 nM-1 μM, and the detection limits were 1 nM and 4.2 nM, respectively. Both chemosensors also enable the visualization of Hg2+ accumulated in the nematode Caenorhabditis elegans previously exposed to nanomolar concentrations of Hg 2+.

Original languageEnglish
Pages (from-to)1339-1343
Number of pages5
JournalAnalyst
Volume136
Issue number7
DOIs
StatePublished - 7 Apr 2011

Fingerprint

Dive into the research topics of 'Rhodamine hydrazone derivatives as Hg2+ selective fluorescent and colorimetric chemosensors and their applications to bioimaging and microfluidic system'. Together they form a unique fingerprint.

Cite this