Reverse thermal gelation of PAF-PLX-PAF block copolymer aqueous solution

Eun Hae Kim; Min Kyung Joo; Kyung Hyun Bahk; Min Hee Park; Bo Chi; Young Mi Lee; Byeongmoon Jeong

doi:10.1021/bm9004436

Reverse thermal gelation of PAF-PLX-PAF block copolymer aqueous solution

Eun Hae Kim, Min Kyung Joo, Kyung Hyun Bahk, Min Hee Park, Bo Chi, Young Mi Lee, Byeongmoon Jeong

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The aqueous solution of poly(L-Ala-co-L-Phe)-poly(propylene glycol)-poly(ethylene glycol)-poly(propylene glycol)-poly(L-Ala-co-L-Phe) block copolymers (PAF-PLX-PAF) in a concentration range of 6.0-10.0 wt % underwent sol-to-gel transition as the temperature increased from 10 to 50 ° C. Circular dichroism spectra, hydrophobic dye solubilization, dynamic light scattering, and transmission electron microscopy image of the polymer suggest that the polymers form micelles in water, where the hydrophilic (PLX) blocks form a shell and the hydrophobic (PAF) blocks form a core of the micelle. Circular dichroism, FTIR, and ¹³C NMR spectra suggest that sol-to-gel transition accompanies partial strengthening of the β-sheet structure of PAF and a decrease in molecular motion of the PLX. The sol-to-gel transition temperature could be controlled by varying the molecular weight of PAF and PLX blocks, the ratio of Ala to Phe, and the corresponding secondary structure of the polypeptide.

Original language	English
Pages (from-to)	2476-2481
Number of pages	6
Journal	Biomacromolecules
Volume	10
Issue number	9
DOIs	https://doi.org/10.1021/bm9004436
State	Published - 14 Sep 2009

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@article{35a7c2984ed241c3b19f7d754aac80d9,

title = "Reverse thermal gelation of PAF-PLX-PAF block copolymer aqueous solution",

abstract = "The aqueous solution of poly(L-Ala-co-L-Phe)-poly(propylene glycol)-poly(ethylene glycol)-poly(propylene glycol)-poly(L-Ala-co-L-Phe) block copolymers (PAF-PLX-PAF) in a concentration range of 6.0-10.0 wt % underwent sol-to-gel transition as the temperature increased from 10 to 50 ° C. Circular dichroism spectra, hydrophobic dye solubilization, dynamic light scattering, and transmission electron microscopy image of the polymer suggest that the polymers form micelles in water, where the hydrophilic (PLX) blocks form a shell and the hydrophobic (PAF) blocks form a core of the micelle. Circular dichroism, FTIR, and 13C NMR spectra suggest that sol-to-gel transition accompanies partial strengthening of the β-sheet structure of PAF and a decrease in molecular motion of the PLX. The sol-to-gel transition temperature could be controlled by varying the molecular weight of PAF and PLX blocks, the ratio of Ala to Phe, and the corresponding secondary structure of the polypeptide.",

author = "Kim, {Eun Hae} and Joo, {Min Kyung} and Bahk, {Kyung Hyun} and Park, {Min Hee} and Bo Chi and Lee, {Young Mi} and Byeongmoon Jeong",

year = "2009",

month = sep,

day = "14",

doi = "10.1021/bm9004436",

language = "English",

volume = "10",

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journal = "Biomacromolecules",

issn = "1525-7797",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Reverse thermal gelation of PAF-PLX-PAF block copolymer aqueous solution

AU - Kim, Eun Hae

AU - Joo, Min Kyung

AU - Bahk, Kyung Hyun

AU - Park, Min Hee

AU - Chi, Bo

AU - Lee, Young Mi

AU - Jeong, Byeongmoon

PY - 2009/9/14

Y1 - 2009/9/14

N2 - The aqueous solution of poly(L-Ala-co-L-Phe)-poly(propylene glycol)-poly(ethylene glycol)-poly(propylene glycol)-poly(L-Ala-co-L-Phe) block copolymers (PAF-PLX-PAF) in a concentration range of 6.0-10.0 wt % underwent sol-to-gel transition as the temperature increased from 10 to 50 ° C. Circular dichroism spectra, hydrophobic dye solubilization, dynamic light scattering, and transmission electron microscopy image of the polymer suggest that the polymers form micelles in water, where the hydrophilic (PLX) blocks form a shell and the hydrophobic (PAF) blocks form a core of the micelle. Circular dichroism, FTIR, and 13C NMR spectra suggest that sol-to-gel transition accompanies partial strengthening of the β-sheet structure of PAF and a decrease in molecular motion of the PLX. The sol-to-gel transition temperature could be controlled by varying the molecular weight of PAF and PLX blocks, the ratio of Ala to Phe, and the corresponding secondary structure of the polypeptide.

AB - The aqueous solution of poly(L-Ala-co-L-Phe)-poly(propylene glycol)-poly(ethylene glycol)-poly(propylene glycol)-poly(L-Ala-co-L-Phe) block copolymers (PAF-PLX-PAF) in a concentration range of 6.0-10.0 wt % underwent sol-to-gel transition as the temperature increased from 10 to 50 ° C. Circular dichroism spectra, hydrophobic dye solubilization, dynamic light scattering, and transmission electron microscopy image of the polymer suggest that the polymers form micelles in water, where the hydrophilic (PLX) blocks form a shell and the hydrophobic (PAF) blocks form a core of the micelle. Circular dichroism, FTIR, and 13C NMR spectra suggest that sol-to-gel transition accompanies partial strengthening of the β-sheet structure of PAF and a decrease in molecular motion of the PLX. The sol-to-gel transition temperature could be controlled by varying the molecular weight of PAF and PLX blocks, the ratio of Ala to Phe, and the corresponding secondary structure of the polypeptide.

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U2 - 10.1021/bm9004436

DO - 10.1021/bm9004436

M3 - Article

C2 - 19637909

AN - SCOPUS:70349186920

SN - 1525-7797

VL - 10

SP - 2476

EP - 2481

JO - Biomacromolecules

JF - Biomacromolecules

IS - 9

ER -

Reverse thermal gelation of PAF-PLX-PAF block copolymer aqueous solution

Abstract

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