Retinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cells

Jeong Hoon Lee; Jung Hwan Yoon; Su Jong Yu; Goh Eun Chung; Eun Uk Jung; Hwi Young Kim; Bo Hyun Kim; Dae Hee Choi; Sun Jung Myung; Yoon Jun Kim; Chung Yong Kim; Hyo Suk Lee

doi:10.1016/j.canlet.2010.03.005

Retinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cells

Jeong Hoon Lee, Jung Hwan Yoon, Su Jong Yu, Goh Eun Chung, Eun Uk Jung, Hwi Young Kim, Bo Hyun Kim, Dae Hee Choi, Sun Jung Myung, Yoon Jun Kim, Chung Yong Kim, Hyo Suk Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a ligand for CRABP-II, induced HCC cell apoptosis more effectively in hypoxia than in normoxia, whereas hypoxia-induced CRABP-II expression attenuated RA-induced apoptosis. Inhibition of CRABP-II enhanced RA-induced apoptosis and sensitized RA-resistant HCC cells to RA cytotoxicity by attenuating p42/44 MAPK and Akt activation. Therefore, RA/CRABP-II signal modulation is therapeutically implicated in infiltrative HCCs exposed to hypoxia.

Original language	English
Pages (from-to)	229-235
Number of pages	7
Journal	Cancer Letters
Volume	295
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2010.03.005
State	Published - Sep 2010

Keywords

Apoptosis
Cellular retinoic acid binding protein-II
Hepatocellular carcinoma
Hypoxia
Retinoic acid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2010.03.005

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title = "Retinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cells",

abstract = "Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a ligand for CRABP-II, induced HCC cell apoptosis more effectively in hypoxia than in normoxia, whereas hypoxia-induced CRABP-II expression attenuated RA-induced apoptosis. Inhibition of CRABP-II enhanced RA-induced apoptosis and sensitized RA-resistant HCC cells to RA cytotoxicity by attenuating p42/44 MAPK and Akt activation. Therefore, RA/CRABP-II signal modulation is therapeutically implicated in infiltrative HCCs exposed to hypoxia.",

keywords = "Apoptosis, Cellular retinoic acid binding protein-II, Hepatocellular carcinoma, Hypoxia, Retinoic acid",

author = "Lee, {Jeong Hoon} and Yoon, {Jung Hwan} and Yu, {Su Jong} and Chung, {Goh Eun} and Jung, {Eun Uk} and Kim, {Hwi Young} and Kim, {Bo Hyun} and Choi, {Dae Hee} and Myung, {Sun Jung} and Kim, {Yoon Jun} and Kim, {Chung Yong} and Lee, {Hyo Suk}",

year = "2010",

month = sep,

doi = "10.1016/j.canlet.2010.03.005",

language = "English",

volume = "295",

pages = "229--235",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

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T1 - Retinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cells

AU - Lee, Jeong Hoon

AU - Yoon, Jung Hwan

AU - Yu, Su Jong

AU - Chung, Goh Eun

AU - Jung, Eun Uk

AU - Kim, Hwi Young

AU - Kim, Bo Hyun

AU - Choi, Dae Hee

AU - Myung, Sun Jung

AU - Kim, Yoon Jun

AU - Kim, Chung Yong

AU - Lee, Hyo Suk

PY - 2010/9

Y1 - 2010/9

N2 - Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a ligand for CRABP-II, induced HCC cell apoptosis more effectively in hypoxia than in normoxia, whereas hypoxia-induced CRABP-II expression attenuated RA-induced apoptosis. Inhibition of CRABP-II enhanced RA-induced apoptosis and sensitized RA-resistant HCC cells to RA cytotoxicity by attenuating p42/44 MAPK and Akt activation. Therefore, RA/CRABP-II signal modulation is therapeutically implicated in infiltrative HCCs exposed to hypoxia.

AB - Hypoxia induces survival signals in hepatocellular carcinoma (HCC). We attempted to find a hypoxia-induced signal that could be used for modulating HCC cell death. Cellular retinoic acid binding protein-II (CRABP-II) expression was significantly increased in hypoxic HCC cells. Treatment with retinoic acid (RA), a ligand for CRABP-II, induced HCC cell apoptosis more effectively in hypoxia than in normoxia, whereas hypoxia-induced CRABP-II expression attenuated RA-induced apoptosis. Inhibition of CRABP-II enhanced RA-induced apoptosis and sensitized RA-resistant HCC cells to RA cytotoxicity by attenuating p42/44 MAPK and Akt activation. Therefore, RA/CRABP-II signal modulation is therapeutically implicated in infiltrative HCCs exposed to hypoxia.

KW - Apoptosis

KW - Cellular retinoic acid binding protein-II

KW - Hepatocellular carcinoma

KW - Hypoxia

KW - Retinoic acid

UR - http://www.scopus.com/inward/record.url?scp=77954031010&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2010.03.005

DO - 10.1016/j.canlet.2010.03.005

M3 - Article

C2 - 20350780

AN - SCOPUS:77954031010

SN - 0304-3835

VL - 295

SP - 229

EP - 235

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Retinoic acid and its binding protein modulate apoptotic signals in hypoxic hepatocellular carcinoma cells

Abstract

Keywords

UN SDGs

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