TY - JOUR
T1 - Resveratrol tetramers from Vatica diospyroides
AU - Seo, Eun Kyoung
AU - Chai, Heebyung
AU - Constant, Howard L.
AU - Santisuk, Thawatchai
AU - Reutrakul, Vichai
AU - Beecher, Christopher W.W.
AU - Farnsworth, Norman R.
AU - Cordell, Geoffrey A.
AU - Pezzuto, John M.
AU - Kinghorn, A. Douglas
PY - 1999/9/17
Y1 - 1999/9/17
N2 - Vatdiospyroidol (1), a novel cytotoxic resveratrol tetramer, was isolated from the stems of Vatica diospyroides Sym. (Dipterocarpaceae) by bioassay-guided fractionation monitored with a human oral epidermoid carcinoma (KB) cell line. Another novel resveratrol tetramer, vaticaphenol A (2), was obtained as a noncytotoxic constituent, along with the known compounds, bergenin, betulin, betulinic acid, mangiferonic acid, and (E)- resveratrol 3-O-β-D-glucopyranoside. The structures of compounds 1 and 2 were elucidated by spectral analysis, including 1D and 2D NMR experiments, and by molecular modeling.
AB - Vatdiospyroidol (1), a novel cytotoxic resveratrol tetramer, was isolated from the stems of Vatica diospyroides Sym. (Dipterocarpaceae) by bioassay-guided fractionation monitored with a human oral epidermoid carcinoma (KB) cell line. Another novel resveratrol tetramer, vaticaphenol A (2), was obtained as a noncytotoxic constituent, along with the known compounds, bergenin, betulin, betulinic acid, mangiferonic acid, and (E)- resveratrol 3-O-β-D-glucopyranoside. The structures of compounds 1 and 2 were elucidated by spectral analysis, including 1D and 2D NMR experiments, and by molecular modeling.
UR - http://www.scopus.com/inward/record.url?scp=0033578950&partnerID=8YFLogxK
U2 - 10.1021/jo9902087
DO - 10.1021/jo9902087
M3 - Article
AN - SCOPUS:0033578950
SN - 0022-3263
VL - 64
SP - 6976
EP - 6983
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 19
ER -