Resveratrol tetramers from Vatica diospyroides

Eun Kyoung Seo, Heebyung Chai, Howard L. Constant, Thawatchai Santisuk, Vichai Reutrakul, Christopher W.W. Beecher, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Vatdiospyroidol (1), a novel cytotoxic resveratrol tetramer, was isolated from the stems of Vatica diospyroides Sym. (Dipterocarpaceae) by bioassay-guided fractionation monitored with a human oral epidermoid carcinoma (KB) cell line. Another novel resveratrol tetramer, vaticaphenol A (2), was obtained as a noncytotoxic constituent, along with the known compounds, bergenin, betulin, betulinic acid, mangiferonic acid, and (E)- resveratrol 3-O-β-D-glucopyranoside. The structures of compounds 1 and 2 were elucidated by spectral analysis, including 1D and 2D NMR experiments, and by molecular modeling.

Original languageEnglish
Pages (from-to)6976-6983
Number of pages8
JournalJournal of Organic Chemistry
Volume64
Issue number19
DOIs
StatePublished - 17 Sep 1999

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