Resveratrol-β-Lactoglobulin Composite Nanocoating by Layer-by-Layer Assembly with Fe(III)-Tannic Acid Complex

Yeon Seo Cho, Seulbi Kim, Young Kwan Kim, Sung Giu Jin, Ji Hun Park

Research output: Contribution to journalArticlepeer-review


Resveratrol (3,4’,5-trihydroxystilbene) is beneficial to human health due to its diverse biological activities including its anti-inflammatory and anti-oxidative effects as confirmed by pharmacokinetic tests. Despite these clinical merits, resveratrol's limited hydrosolubility and chemical vulnerability remain challenging with regard to developing a controlled delivery system with enhanced bioavailability. In this work, we report a resveratrol-β-lactoglobulin (R-BLG) composite nanocoating through a layer-by-layer assembly with Fe(III)-tannic acid nanofilms. The R-BLG composite nanocoating can be formed in planar and particulate substrates, showing excellent film stability under a broad range of pH values and against enzymatic digestion during a weeklong incubation. We envision that the proteinaceous nanocoating herein could be combined with existing pharmaceutical carrier materials (e. g., microcapsules and nanoparticles) to realize advanced drug delivery systems with an expanded repertoire of hydrophobic drugs.

Original languageEnglish
Pages (from-to)3636-3639
Number of pages4
JournalChemistry - An Asian Journal
Issue number22
StatePublished - 15 Nov 2021


  • Nanostructures
  • Resveratrol
  • Tannic acid
  • Thin films
  • β-Lactoglobulin


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