Resting cerebral glucose metabolism and perfusion patterns in women with posttraumatic stress disorder related to sexual assault

Shin Young Kim, Young Ki Chung, Bom Sahn Kim, Su Jin Lee, Joon Kee Yoon, Young Sil An

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

In the literature, numerous trials using neuroimaging techniques have investigated brain function in patients with post-traumatic stress disorder (PTSD). However, the contrasting results showed that improvements, including in the study design, were required to reach consistent and convincing conclusions. This study evaluated the functional neuroimaging pattern of resting cerebral blood flow and glucose metabolism in patients with PTSD related to sexual assault. Twelve patients were enrolled for both brain single photon emission computed tomography (SPECT) and 18F-fluorodeoxyglucose positron emission tomography (PET) investigations. All data were analyzed with statistical parametric mapping 2 (SPM2). The PTSD patients showed significant relative decreases in perfusion in the left hippocampus and in the basal ganglia compared with the control group. The PTSD group also had significantly lower cerebral glucosemetabolic activity in the left hippocampus and the superior temporal and precentral gyri than in the control group. These specific patterns of perfusion and glucose metabolism may be closely related to various neurophysiologic symptoms of PTSD.

Original languageEnglish
Pages (from-to)214-217
Number of pages4
JournalPsychiatry Research - Neuroimaging
Volume201
Issue number3
DOIs
StatePublished - 31 Mar 2012

Keywords

  • F-fluorodeoxyglucose
  • Positron emission tomography
  • Post-traumatic
  • Single photon emission computed tomography
  • Stress disorders

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