Reorganization of horizontal cell processes in the developing FVB/N mouse retina

Sung Jin Park; In Beom Kim; Kyu Ryong Choi; Jung Il Moon; Su Ja Oh; Jin Woong Chung; Myung Hoon Chun

doi:10.1007/s004410100453

Reorganization of horizontal cell processes in the developing FVB/N mouse retina

Sung Jin Park, In Beom Kim, Kyu Ryong Choi, Jung Il Moon, Su Ja Oh, Jin Woong Chung, Myung Hoon Chun

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We investigated the morphological changes of horizontal cells after postnatal photoreceptor degeneration in the developing FVB/N mouse retina, using immunocytochemistry with anti-calbindin D-28K. From postnatal day 14 (P14) onwards, processes emerging from horizontal cells descend into the inner plexiform layer (IPL) and ramify mainly in stratum 1 of the IPL. Electron microscopy revealed that the descending processes make synaptic contacts with bipolar cells in the outer plexiform layer. Our results clearly demonstrate that loss of photoreceptor cells induces the reorganization of horizontal cell processes in the retinas of FVB/N mice as they mature.

Original language	English
Pages (from-to)	341-346
Number of pages	6
Journal	Cell and Tissue Research
Volume	306
Issue number	2
DOIs	https://doi.org/10.1007/s004410100453
State	Published - 2001

Bibliographical note

Funding Information:
This work was supported by a Korea Research Foundation Grant (FP 0005) of the Republic of Korea. We are grateful to H.-D. Rho and B.-W. Hong for their technical assistance

Keywords

Horizontal cells
Immunocytochemistry
Mouse (FVB/N)
Plasticity
Retinal degeneration

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10.1007/s004410100453

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title = "Reorganization of horizontal cell processes in the developing FVB/N mouse retina",

abstract = "We investigated the morphological changes of horizontal cells after postnatal photoreceptor degeneration in the developing FVB/N mouse retina, using immunocytochemistry with anti-calbindin D-28K. From postnatal day 14 (P14) onwards, processes emerging from horizontal cells descend into the inner plexiform layer (IPL) and ramify mainly in stratum 1 of the IPL. Electron microscopy revealed that the descending processes make synaptic contacts with bipolar cells in the outer plexiform layer. Our results clearly demonstrate that loss of photoreceptor cells induces the reorganization of horizontal cell processes in the retinas of FVB/N mice as they mature.",

keywords = "Horizontal cells, Immunocytochemistry, Mouse (FVB/N), Plasticity, Retinal degeneration",

author = "Park, {Sung Jin} and Kim, {In Beom} and Choi, {Kyu Ryong} and Moon, {Jung Il} and Oh, {Su Ja} and Chung, {Jin Woong} and Chun, {Myung Hoon}",

note = "Funding Information: This work was supported by a Korea Research Foundation Grant (FP 0005) of the Republic of Korea. We are grateful to H.-D. Rho and B.-W. Hong for their technical assistance",

year = "2001",

doi = "10.1007/s004410100453",

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volume = "306",

pages = "341--346",

journal = "Cell and Tissue Research",

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T1 - Reorganization of horizontal cell processes in the developing FVB/N mouse retina

AU - Park, Sung Jin

AU - Kim, In Beom

AU - Choi, Kyu Ryong

AU - Moon, Jung Il

AU - Oh, Su Ja

AU - Chung, Jin Woong

AU - Chun, Myung Hoon

N1 - Funding Information: This work was supported by a Korea Research Foundation Grant (FP 0005) of the Republic of Korea. We are grateful to H.-D. Rho and B.-W. Hong for their technical assistance

PY - 2001

Y1 - 2001

N2 - We investigated the morphological changes of horizontal cells after postnatal photoreceptor degeneration in the developing FVB/N mouse retina, using immunocytochemistry with anti-calbindin D-28K. From postnatal day 14 (P14) onwards, processes emerging from horizontal cells descend into the inner plexiform layer (IPL) and ramify mainly in stratum 1 of the IPL. Electron microscopy revealed that the descending processes make synaptic contacts with bipolar cells in the outer plexiform layer. Our results clearly demonstrate that loss of photoreceptor cells induces the reorganization of horizontal cell processes in the retinas of FVB/N mice as they mature.

AB - We investigated the morphological changes of horizontal cells after postnatal photoreceptor degeneration in the developing FVB/N mouse retina, using immunocytochemistry with anti-calbindin D-28K. From postnatal day 14 (P14) onwards, processes emerging from horizontal cells descend into the inner plexiform layer (IPL) and ramify mainly in stratum 1 of the IPL. Electron microscopy revealed that the descending processes make synaptic contacts with bipolar cells in the outer plexiform layer. Our results clearly demonstrate that loss of photoreceptor cells induces the reorganization of horizontal cell processes in the retinas of FVB/N mice as they mature.

KW - Horizontal cells

KW - Immunocytochemistry

KW - Mouse (FVB/N)

KW - Plasticity

KW - Retinal degeneration

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JO - Cell and Tissue Research

JF - Cell and Tissue Research

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Reorganization of horizontal cell processes in the developing FVB/N mouse retina

Abstract

Bibliographical note

Keywords

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