Reorganization of horizontal cell processes in the developing FVB/N mouse retina

Sung Jin Park, In Beom Kim, Kyu Ryong Choi, Jung Il Moon, Su Ja Oh, Jin Woong Chung, Myung Hoon Chun

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


We investigated the morphological changes of horizontal cells after postnatal photoreceptor degeneration in the developing FVB/N mouse retina, using immunocytochemistry with anti-calbindin D-28K. From postnatal day 14 (P14) onwards, processes emerging from horizontal cells descend into the inner plexiform layer (IPL) and ramify mainly in stratum 1 of the IPL. Electron microscopy revealed that the descending processes make synaptic contacts with bipolar cells in the outer plexiform layer. Our results clearly demonstrate that loss of photoreceptor cells induces the reorganization of horizontal cell processes in the retinas of FVB/N mice as they mature.

Original languageEnglish
Pages (from-to)341-346
Number of pages6
JournalCell and Tissue Research
Issue number2
StatePublished - 2001

Bibliographical note

Funding Information:
This work was supported by a Korea Research Foundation Grant (FP 0005) of the Republic of Korea. We are grateful to H.-D. Rho and B.-W. Hong for their technical assistance


  • Horizontal cells
  • Immunocytochemistry
  • Mouse (FVB/N)
  • Plasticity
  • Retinal degeneration


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