Remote optical switch for localized and selective control of gene interference

Somin Eunice Lee, Gang Logan Liu, Franklin Kim, Luke P. Lee

Research output: Contribution to journalArticlepeer-review

204 Scopus citations

Abstract

Near infrared-absorbing gold nanoplasmonic particles (GNPs) are used as optical switches of gene interference and are remotely controlled using light. We have tuned optical switches to a wavelength where cellular photodamage is minimized. Optical switches are functionalized with double-stranded oligonucleotides. At desired times and at specific intracellular locations, remote optical excitation is used to liberate gene-interfering oligonucleotides. We demonstrate a novel gene-interfering technique offering spatial and temporal control, which is otherwise impossible using conventional gene-interfering techniques.

Original languageEnglish
Pages (from-to)562-570
Number of pages9
JournalNano Letters
Volume9
Issue number2
DOIs
StatePublished - 11 Feb 2009

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