Remote-Controlled Release of Singlet Oxygen by the Plasmonic Heating of Endoperoxide-Modified Gold Nanorods: Towards a Paradigm Change in Photodynamic Therapy

Safacan Kolemen, Tugba Ozdemir, Dayoung Lee, Gyoung Mi Kim, Tugce Karatas, Juyoung Yoon, Engin U. Akkaya

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

The photodynamic therapy of cancer is contingent upon the sustained generation of singlet oxygen in the tumor region. However, tumors of the most metastatic cancer types develop a region of severe hypoxia, which puts them beyond the reach of most therapeutic protocols. More troublesome, photodynamic action generates acute hypoxia as the process itself diminishes cellular oxygen reserves, which makes it a self-limiting method. Herein, we describe a new concept that could eventually lead to a change in the 100 year old paradigm of photodynamic therapy and potentially offer solutions to some of the lingering problems. When gold nanorods with tethered endoperoxides are irradiated at 808 nm, the endoperoxides undergo thermal cycloreversion, resulting in the generation of singlet oxygen. We demonstrate that the amount of singlet oxygen produced in this way is sufficient for triggering apoptosis in cell cultures. EPT sees the light: When gold nanorods with tethered endoperoxides are irradiated with near-infrared light, the endoperoxides undergo thermal cycloreversion, resulting in the generation of singlet oxygen. The amount of singlet oxygen generated by these nanocomposites is sufficient for triggering apoptosis in cell cultures.

Original languageEnglish
Pages (from-to)3606-3610
Number of pages5
JournalAngewandte Chemie - International Edition
Volume55
Issue number11
DOIs
StatePublished - 7 Mar 2016

Keywords

  • endoperoxides
  • nanorods
  • photodynamic therapy
  • photosensitizers
  • singlet oxygen

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