Abstract
The concentration of micronutrients impacts fetal development and pregnancy outcome and has been suggested to be negatively correlated with the body-mass index (BMI). We evaluated the relationship between BMI and the serum folate concentration in 802 and 660 Korean pregnant women in mid- and late pregnancy, respectively, who participated in a multicenter prospective study. There was a significant negative correlation between BMI value and the serum folate concentration at mid- and late pregnancy (P for trend 0.001 and 0.024, respectively). A general linear model confirmed this correlation at both time points after adjusting for gestational age and total folate intake. These findings are important as the serum folate concentration is a rate-limiting factor for placental folate transport to the fetus, and an inadequate folate supply may cause various malformations.
Original language | English |
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Pages (from-to) | 136-138 |
Number of pages | 3 |
Journal | European Journal of Clinical Nutrition |
Volume | 66 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2012 |
Keywords
- body-mass index
- folate
- human
- malformations
- pregnancy
- serum