Relationship between body-mass index and serum folate concentrations in pregnant women

H. Kim; J. Y. Hwang; K. N. Kim; E. H. Ha; H. Park; M. Ha; K. Y. Lee; Y. C. Hong; T. Tamura; N. Chang

doi:10.1038/ejcn.2011.160

Relationship between body-mass index and serum folate concentrations in pregnant women

H. Kim, J. Y. Hwang, K. N. Kim, E. H. Ha, H. Park, M. Ha, K. Y. Lee, Y. C. Hong, T. Tamura, N. Chang

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The concentration of micronutrients impacts fetal development and pregnancy outcome and has been suggested to be negatively correlated with the body-mass index (BMI). We evaluated the relationship between BMI and the serum folate concentration in 802 and 660 Korean pregnant women in mid- and late pregnancy, respectively, who participated in a multicenter prospective study. There was a significant negative correlation between BMI value and the serum folate concentration at mid- and late pregnancy (P for trend 0.001 and 0.024, respectively). A general linear model confirmed this correlation at both time points after adjusting for gestational age and total folate intake. These findings are important as the serum folate concentration is a rate-limiting factor for placental folate transport to the fetus, and an inadequate folate supply may cause various malformations.

Original language	English
Pages (from-to)	136-138
Number of pages	3
Journal	European Journal of Clinical Nutrition
Volume	66
Issue number	1
DOIs	https://doi.org/10.1038/ejcn.2011.160
State	Published - Jan 2012

Bibliographical note

Funding Information:
This study was supported by the Mothers and Children’s Environmental Health (MOCEH) Project of the Ministry of Environment, and the 2nd stage of Brain Korea 21 project, Republic of Korea. The visiting research professorship (Tsunenobu Tamura) was supported by the Korea Research Foundation and the Korean Federation of Science and Technology Societies Grant funded by the Korea Government (MOEHRD, Basic Research Promotion Fund; 091S-4-3-0222).

Keywords

body-mass index
folate
human
malformations
pregnancy
serum

Access to Document

10.1038/ejcn.2011.160

Cite this

@article{9b7565186fe44d27b2c8acf263e9da8a,

title = "Relationship between body-mass index and serum folate concentrations in pregnant women",

abstract = "The concentration of micronutrients impacts fetal development and pregnancy outcome and has been suggested to be negatively correlated with the body-mass index (BMI). We evaluated the relationship between BMI and the serum folate concentration in 802 and 660 Korean pregnant women in mid- and late pregnancy, respectively, who participated in a multicenter prospective study. There was a significant negative correlation between BMI value and the serum folate concentration at mid- and late pregnancy (P for trend 0.001 and 0.024, respectively). A general linear model confirmed this correlation at both time points after adjusting for gestational age and total folate intake. These findings are important as the serum folate concentration is a rate-limiting factor for placental folate transport to the fetus, and an inadequate folate supply may cause various malformations.",

keywords = "body-mass index, folate, human, malformations, pregnancy, serum",

author = "H. Kim and Hwang, {J. Y.} and Kim, {K. N.} and Ha, {E. H.} and H. Park and M. Ha and Lee, {K. Y.} and Hong, {Y. C.} and T. Tamura and N. Chang",

note = "Funding Information: This study was supported by the Mothers and Children{\textquoteright}s Environmental Health (MOCEH) Project of the Ministry of Environment, and the 2nd stage of Brain Korea 21 project, Republic of Korea. The visiting research professorship (Tsunenobu Tamura) was supported by the Korea Research Foundation and the Korean Federation of Science and Technology Societies Grant funded by the Korea Government (MOEHRD, Basic Research Promotion Fund; 091S-4-3-0222).",

year = "2012",

month = jan,

doi = "10.1038/ejcn.2011.160",

language = "English",

volume = "66",

pages = "136--138",

journal = "European Journal of Clinical Nutrition",

issn = "0954-3007",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Relationship between body-mass index and serum folate concentrations in pregnant women

AU - Kim, H.

AU - Hwang, J. Y.

AU - Kim, K. N.

AU - Ha, E. H.

AU - Park, H.

AU - Ha, M.

AU - Lee, K. Y.

AU - Hong, Y. C.

AU - Tamura, T.

AU - Chang, N.

N1 - Funding Information: This study was supported by the Mothers and Children’s Environmental Health (MOCEH) Project of the Ministry of Environment, and the 2nd stage of Brain Korea 21 project, Republic of Korea. The visiting research professorship (Tsunenobu Tamura) was supported by the Korea Research Foundation and the Korean Federation of Science and Technology Societies Grant funded by the Korea Government (MOEHRD, Basic Research Promotion Fund; 091S-4-3-0222).

PY - 2012/1

Y1 - 2012/1

N2 - The concentration of micronutrients impacts fetal development and pregnancy outcome and has been suggested to be negatively correlated with the body-mass index (BMI). We evaluated the relationship between BMI and the serum folate concentration in 802 and 660 Korean pregnant women in mid- and late pregnancy, respectively, who participated in a multicenter prospective study. There was a significant negative correlation between BMI value and the serum folate concentration at mid- and late pregnancy (P for trend 0.001 and 0.024, respectively). A general linear model confirmed this correlation at both time points after adjusting for gestational age and total folate intake. These findings are important as the serum folate concentration is a rate-limiting factor for placental folate transport to the fetus, and an inadequate folate supply may cause various malformations.

AB - The concentration of micronutrients impacts fetal development and pregnancy outcome and has been suggested to be negatively correlated with the body-mass index (BMI). We evaluated the relationship between BMI and the serum folate concentration in 802 and 660 Korean pregnant women in mid- and late pregnancy, respectively, who participated in a multicenter prospective study. There was a significant negative correlation between BMI value and the serum folate concentration at mid- and late pregnancy (P for trend 0.001 and 0.024, respectively). A general linear model confirmed this correlation at both time points after adjusting for gestational age and total folate intake. These findings are important as the serum folate concentration is a rate-limiting factor for placental folate transport to the fetus, and an inadequate folate supply may cause various malformations.

KW - body-mass index

KW - folate

KW - human

KW - malformations

KW - pregnancy

KW - serum

UR - http://www.scopus.com/inward/record.url?scp=84855493278&partnerID=8YFLogxK

U2 - 10.1038/ejcn.2011.160

DO - 10.1038/ejcn.2011.160

M3 - Article

C2 - 21934699

AN - SCOPUS:84855493278

SN - 0954-3007

VL - 66

SP - 136

EP - 138

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 1

ER -

Relationship between body-mass index and serum folate concentrations in pregnant women

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this