Relation between serum folate status and blood mercury concentrations in pregnant women

Hyesook Kim, Ki Nam Kim, Ji Yun Hwang, Eun Hee Ha, Hyesook Park, Mina Ha, Yangho Kim, Yun Chul Hong, Namsoo Chang

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objective: To evaluate the relation between maternal serum folate status and blood mercury in pregnant Korean women. Methods: The nutritional status of folate and the blood mercury concentration were measured in pregnant Korean women who participated in a multicenter prospective study from 2006 through 2011. We analyzed existing blood mercury data based on serum folate status at two gestational time points (mid and late pregnancy, n = 1105 and 841, respectively). Results: Serum folate concentrations in pregnant women were negatively associated with blood mercury concentrations at mid and late pregnancy (P trend = 0.012 and 0.002, respectively). A general linear model developed after adjusting for covariates indicated a significant negative association between the two at mid and late pregnancy. Conclusion: We found a negative association between serum folate and blood mercury concentrations in pregnant Korean women.

Original languageEnglish
Pages (from-to)514-518
Number of pages5
Issue number3
StatePublished - Mar 2013

Bibliographical note

Funding Information:
This study was supported by the Mothers and Children's Environmental Health (MOCEH) Project of the Ministry of Environment , Republic of Korea.


  • Folate intake
  • Mercury
  • Pregnant women
  • Serum folate


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