Regulation of the 5-HT3A receptor-mediated current by alkyl 4-hydroxybenzoates isolated from the seeds of Nelumbo nucifera

Ui Joung Youn, Jun Ho Lee, Yoo Jin Lee, Joo Won Nam, Hyunsu Bae, Eun Kyoung Seo

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Four known alkyl 4-hydroxybenzoates, i.e., methyl 4-hydroxybenzoate (1), ethyl 4-hydroxybenzoate (2), propyl 4-hydroxybenzoate (3), and butyl 4-hydroxybenzoate (4), were isolated from the seeds of Nelumbo nucifera GAERTNER (Nymphaeaceae) for the first time. The structures of the isolates were identified by 1D- and 2D-NMR spectroscopy and comparison with published values. The compounds were evaluated for their effects on the 5-HT-stimulated inward current (I5-HT) mediated by the human 5-HT3A receptors expressed in Xenopus oocytes. Compounds 1 and 2 enhanced the I5-HT, but 4 reduced it. These results indicate that 4 is an inhibitor of the 5-HT 3A receptors expressed in Xenopus oocytes.

Original languageEnglish
Pages (from-to)2296-2302
Number of pages7
JournalChemistry and Biodiversity
Volume7
Issue number9
DOIs
StatePublished - Sep 2010

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