Regulation of redox potential of a pterin derivative bound to a ruthenium(II) complex by intermolecular hydrogen bonding with nucleobases

Yuji Inui; Soushi Miyazaki; Kei Ohkubo; Shunichi Fukuzumi; Takahiko Kojima

doi:10.1002/anie.201108827

Regulation of redox potential of a pterin derivative bound to a ruthenium(II) complex by intermolecular hydrogen bonding with nucleobases

Yuji Inui, Soushi Miyazaki, Kei Ohkubo, Shunichi Fukuzumi, Takahiko Kojima

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Potential control: A Ru ^II-bound pterin forms a stable hydrogen-bonding adduct with a guanine derivative through three-point recognition. A large positive shift of the reduction potential of the pterin ligand up to +320 mV is observed (see picture). For the thymine derivative, the mode of hydrogen bonding is altered. Regulation of redox potentials of a pterin coenzyme by noncovalent interaction is demonstrated.

Original language	English
Pages (from-to)	4623-4627
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	19
DOIs	https://doi.org/10.1002/anie.201108827
State	Published - 7 May 2012

Keywords

cofactors
hydrogen bonds
nucleobases
redox chemistry
ruthenium

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title = "Regulation of redox potential of a pterin derivative bound to a ruthenium(II) complex by intermolecular hydrogen bonding with nucleobases",

abstract = "Potential control: A Ru II-bound pterin forms a stable hydrogen-bonding adduct with a guanine derivative through three-point recognition. A large positive shift of the reduction potential of the pterin ligand up to +320 mV is observed (see picture). For the thymine derivative, the mode of hydrogen bonding is altered. Regulation of redox potentials of a pterin coenzyme by noncovalent interaction is demonstrated.",

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author = "Yuji Inui and Soushi Miyazaki and Kei Ohkubo and Shunichi Fukuzumi and Takahiko Kojima",

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T1 - Regulation of redox potential of a pterin derivative bound to a ruthenium(II) complex by intermolecular hydrogen bonding with nucleobases

AU - Inui, Yuji

AU - Miyazaki, Soushi

AU - Ohkubo, Kei

AU - Fukuzumi, Shunichi

AU - Kojima, Takahiko

PY - 2012/5/7

Y1 - 2012/5/7

N2 - Potential control: A Ru II-bound pterin forms a stable hydrogen-bonding adduct with a guanine derivative through three-point recognition. A large positive shift of the reduction potential of the pterin ligand up to +320 mV is observed (see picture). For the thymine derivative, the mode of hydrogen bonding is altered. Regulation of redox potentials of a pterin coenzyme by noncovalent interaction is demonstrated.

AB - Potential control: A Ru II-bound pterin forms a stable hydrogen-bonding adduct with a guanine derivative through three-point recognition. A large positive shift of the reduction potential of the pterin ligand up to +320 mV is observed (see picture). For the thymine derivative, the mode of hydrogen bonding is altered. Regulation of redox potentials of a pterin coenzyme by noncovalent interaction is demonstrated.

KW - cofactors

KW - hydrogen bonds

KW - nucleobases

KW - redox chemistry

KW - ruthenium

UR - http://www.scopus.com/inward/record.url?scp=84860735604&partnerID=8YFLogxK

U2 - 10.1002/anie.201108827

DO - 10.1002/anie.201108827

M3 - Article

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AN - SCOPUS:84860735604

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SP - 4623

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 19

ER -

Regulation of redox potential of a pterin derivative bound to a ruthenium(II) complex by intermolecular hydrogen bonding with nucleobases

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Keywords

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