Regulation of redox potential of a pterin derivative bound to a ruthenium(II) complex by intermolecular hydrogen bonding with nucleobases

Yuji Inui, Soushi Miyazaki, Kei Ohkubo, Shunichi Fukuzumi, Takahiko Kojima

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Potential control: A Ru II-bound pterin forms a stable hydrogen-bonding adduct with a guanine derivative through three-point recognition. A large positive shift of the reduction potential of the pterin ligand up to +320 mV is observed (see picture). For the thymine derivative, the mode of hydrogen bonding is altered. Regulation of redox potentials of a pterin coenzyme by noncovalent interaction is demonstrated.

Original languageEnglish
Pages (from-to)4623-4627
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number19
DOIs
StatePublished - 7 May 2012

Keywords

  • cofactors
  • hydrogen bonds
  • nucleobases
  • redox chemistry
  • ruthenium

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