Regulation of reactive oxygen species generation in cell signaling

Yun Soo Bae, Hyunjin Oh, Sue Goo Rhee, Young Do Yoo

Research output: Contribution to journalReview articlepeer-review

470 Scopus citations


Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H2O2) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.

Original languageEnglish
Pages (from-to)491-509
Number of pages19
JournalMolecules and Cells
Issue number6
StatePublished - Dec 2011


  • Apoptosis
  • Cell signaling
  • Cytochrome p450
  • Mitochondria
  • NADPH oxidase
  • Reactive oxygen species


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