Regulation of reactive oxygen species generation in cell signaling

Yun Soo Bae; Hyunjin Oh; Sue Goo Rhee; Young Do Yoo

doi:10.1007/s10059-011-0276-3

Regulation of reactive oxygen species generation in cell signaling

Yun Soo Bae, Hyunjin Oh, Sue Goo Rhee, Young Do Yoo

Department of Life Science

Research output: Contribution to journal › Review article › peer-review

516 Scopus citations

Abstract

Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H₂O₂) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.

Original language	English
Pages (from-to)	491-509
Number of pages	19
Journal	Molecules and Cells
Volume	32
Issue number	6
DOIs	https://doi.org/10.1007/s10059-011-0276-3
State	Published - Dec 2011

Bibliographical note

Funding Information:
This research was supported by B asic Science Research Program (2011-0025760 to YDY), by National Nuclear R&D Program (2011-0006304 to YDY), by the National Core Research Center (grant R15-2006-020-00000-0 to Y.S.B), by World Class University program (R31-2008-000-10010-0 to Y.S.B), by National Research Laboratory program (grant number ROA-2007-000-20004-00 to Y.S.B) of the Ministry of Education, Science and Technology/National Research Foundation of Korea (NRF), and by a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs (1020180 to YDY). H.J.O is recipient of a B rain Korea 21 scholarship.

Keywords

Apoptosis
Cell signaling
Cytochrome p450
Mitochondria
NADPH oxidase
Reactive oxygen species

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10.1007/s10059-011-0276-3

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title = "Regulation of reactive oxygen species generation in cell signaling",

abstract = "Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H2O2) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.",

keywords = "Apoptosis, Cell signaling, Cytochrome p450, Mitochondria, NADPH oxidase, Reactive oxygen species",

author = "Bae, {Yun Soo} and Hyunjin Oh and Rhee, {Sue Goo} and Yoo, {Young Do}",

note = "Funding Information: This research was supported by B asic Science Research Program (2011-0025760 to YDY), by National Nuclear R&D Program (2011-0006304 to YDY), by the National Core Research Center (grant R15-2006-020-00000-0 to Y.S.B), by World Class University program (R31-2008-000-10010-0 to Y.S.B), by National Research Laboratory program (grant number ROA-2007-000-20004-00 to Y.S.B) of the Ministry of Education, Science and Technology/National Research Foundation of Korea (NRF), and by a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs (1020180 to YDY). H.J.O is recipient of a B rain Korea 21 scholarship.",

year = "2011",

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doi = "10.1007/s10059-011-0276-3",

language = "English",

volume = "32",

pages = "491--509",

journal = "Molecules and Cells",

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AU - Bae, Yun Soo

AU - Oh, Hyunjin

AU - Rhee, Sue Goo

AU - Yoo, Young Do

N1 - Funding Information: This research was supported by B asic Science Research Program (2011-0025760 to YDY), by National Nuclear R&D Program (2011-0006304 to YDY), by the National Core Research Center (grant R15-2006-020-00000-0 to Y.S.B), by World Class University program (R31-2008-000-10010-0 to Y.S.B), by National Research Laboratory program (grant number ROA-2007-000-20004-00 to Y.S.B) of the Ministry of Education, Science and Technology/National Research Foundation of Korea (NRF), and by a grant from the National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs (1020180 to YDY). H.J.O is recipient of a B rain Korea 21 scholarship.

PY - 2011/12

Y1 - 2011/12

N2 - Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H2O2) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.

AB - Reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide (H2O2) are thought to be byproducts of aerobic respiration with damaging effects on DNA, protein, and lipid. A growing body of evidence indicates, however, that ROS are involved in the maintenance of redox homeostasis and various cellular signaling pathways. ROS are generated from diverse sources including mitochondrial respiratory chain, enzymatic activation of cytochrome p450, and NADPH oxidases further suggesting involvement in a complex array of cellular processes. This review summarizes the production and function of ROS. In particular, how cytosolic and membrane proteins regulate ROS generation for intracellular redox signaling will be detailed.

KW - Apoptosis

KW - Cell signaling

KW - Cytochrome p450

KW - Mitochondria

KW - NADPH oxidase

KW - Reactive oxygen species

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DO - 10.1007/s10059-011-0276-3

M3 - Review article

C2 - 22207195

AN - SCOPUS:84859897794

SN - 1016-8478

VL - 32

SP - 491

EP - 509

JO - Molecules and Cells

JF - Molecules and Cells

IS - 6

ER -

Regulation of reactive oxygen species generation in cell signaling

Abstract

Bibliographical note

Keywords

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