TY - JOUR
T1 - Regulation of phospholipase C isozymes
T2 - Activation of phospholipase C-γ in the absence of tyrosine-phosphorylation
AU - Sekiya, Fujio
AU - Bae, Yun Soo
AU - Rhee, Sue Goo
PY - 1999/4
Y1 - 1999/4
N2 - Activation of PLC-γ isozymes in response to various agonists involves tyrosine phosphorylation of the effector enzymes. Recent evidence indicates that PLC-γ isozymes are additionally activated by phosphatidic acid, phosphatidylinositol 3,4,5-trisphosphate and arachidonic acid in the absence of PLC-γ tyrosine phosphorylation. These lipid-derived messengers are the immediate products of phospholipase D, phosphatidylinositol 3-kinase, and phospholipase A2, enzymes which are often stimulated along with PLC-γ in response to an agonist. Furthermore, phosphatidylinositol 4,5-bisphosphate acts as a substrate for both PLC-γ and phosphatidylinositol 3-kinase and as an activator for phospholipase D and phospholipase A2. These results reveal an elaborate mechanism of cross-talk and mutual regulation between four effector enzymes that participate in receptor signaling by acting on phospholipids. Copyright (C) 1999 Elsevier Science Ireland Ltd.
AB - Activation of PLC-γ isozymes in response to various agonists involves tyrosine phosphorylation of the effector enzymes. Recent evidence indicates that PLC-γ isozymes are additionally activated by phosphatidic acid, phosphatidylinositol 3,4,5-trisphosphate and arachidonic acid in the absence of PLC-γ tyrosine phosphorylation. These lipid-derived messengers are the immediate products of phospholipase D, phosphatidylinositol 3-kinase, and phospholipase A2, enzymes which are often stimulated along with PLC-γ in response to an agonist. Furthermore, phosphatidylinositol 4,5-bisphosphate acts as a substrate for both PLC-γ and phosphatidylinositol 3-kinase and as an activator for phospholipase D and phospholipase A2. These results reveal an elaborate mechanism of cross-talk and mutual regulation between four effector enzymes that participate in receptor signaling by acting on phospholipids. Copyright (C) 1999 Elsevier Science Ireland Ltd.
UR - http://www.scopus.com/inward/record.url?scp=0033020808&partnerID=8YFLogxK
U2 - 10.1016/S0009-3084(99)00013-4
DO - 10.1016/S0009-3084(99)00013-4
M3 - Article
C2 - 10358923
AN - SCOPUS:0033020808
SN - 0009-3084
VL - 98
SP - 3
EP - 11
JO - Chemistry and Physics of Lipids
JF - Chemistry and Physics of Lipids
IS - 1-2
ER -