Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukemia 1

Eun Sook Hwang; Jeong Ho Hong; Suk Chul Bae; Yoshiaki Ito; Seung Ki Lee

doi:10.1016/S0014-5793(99)00190-8

Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukemia 1

Eun Sook Hwang, Jeong Ho Hong, Suk Chul Bae, Yoshiaki Ito, Seung Ki Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Both acute myeloid leukemia 1 and c-Fos are regulatory factors of hematopoietic cell differentiation. We identified that the c-fos promoter contains an acute myeloid leukemia 1 binding site at nucleotide positions -6-+14. c-fos promoter activity was induced by transient overexpression of acute myeloid leukemia 1 in Jurkat T-cells, but not by that of the short form of acute myeloid leukemia 1-MTG8, a chimeric acute myeloid leukemia 1 protein. In 32Dcl3 myeloid cells, stable overexpression of acute myeloid leukemia 1-MTG8 blocked the c-fos gene transcription and cell differentiation, but that of acute myeloid leukemia did not. These data suggest that acute myeloid leukemia 1 and acute myeloid leukemia 1-MTG8 reciprocally regulate the myeloid cell differentiation, possibly by the way of regulating c-fos gene transcription. Copyright (C) 1999 Federation of European Biochemical Societies.

Original language	English
Pages (from-to)	86-90
Number of pages	5
Journal	FEBS Letters
Volume	446
Issue number	1
DOIs	https://doi.org/10.1016/S0014-5793(99)00190-8
State	Published - 5 Mar 1999

Bibliographical note

Funding Information:
The c-fos promoter/luciferase reporter gene (pFos-lcf) and pFos(SP65) were generously provided by Dr Ron Prywes, Columbia University, New York, USA and Dr Tom Kerppola, Howard Hughes Medical Institute, Ann Arbor, MI, USA, respectively. This work was supported by the Korean Science and Engineering Foundation (KOSEF).

Keywords

Acute myeloid leukemia 1
Acute myeloid leukemia 1-MTG8
Myeloid cell differentiation
Transcription
c-fos

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10.1016/S0014-5793(99)00190-8

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title = "Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukemia 1",

abstract = "Both acute myeloid leukemia 1 and c-Fos are regulatory factors of hematopoietic cell differentiation. We identified that the c-fos promoter contains an acute myeloid leukemia 1 binding site at nucleotide positions -6-+14. c-fos promoter activity was induced by transient overexpression of acute myeloid leukemia 1 in Jurkat T-cells, but not by that of the short form of acute myeloid leukemia 1-MTG8, a chimeric acute myeloid leukemia 1 protein. In 32Dcl3 myeloid cells, stable overexpression of acute myeloid leukemia 1-MTG8 blocked the c-fos gene transcription and cell differentiation, but that of acute myeloid leukemia did not. These data suggest that acute myeloid leukemia 1 and acute myeloid leukemia 1-MTG8 reciprocally regulate the myeloid cell differentiation, possibly by the way of regulating c-fos gene transcription. Copyright (C) 1999 Federation of European Biochemical Societies.",

keywords = "Acute myeloid leukemia 1, Acute myeloid leukemia 1-MTG8, Myeloid cell differentiation, Transcription, c-fos",

author = "Hwang, {Eun Sook} and Hong, {Jeong Ho} and Bae, {Suk Chul} and Yoshiaki Ito and Lee, {Seung Ki}",

note = "Funding Information: The c-fos promoter/luciferase reporter gene (pFos-lcf) and pFos(SP65) were generously provided by Dr Ron Prywes, Columbia University, New York, USA and Dr Tom Kerppola, Howard Hughes Medical Institute, Ann Arbor, MI, USA, respectively. This work was supported by the Korean Science and Engineering Foundation (KOSEF).",

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Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukemia 1. / Hwang, Eun Sook; Hong, Jeong Ho; Bae, Suk Chul et al.
In: FEBS Letters, Vol. 446, No. 1, 05.03.1999, p. 86-90.

Research output: Contribution to journal › Article › peer-review

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PY - 1999/3/5

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N2 - Both acute myeloid leukemia 1 and c-Fos are regulatory factors of hematopoietic cell differentiation. We identified that the c-fos promoter contains an acute myeloid leukemia 1 binding site at nucleotide positions -6-+14. c-fos promoter activity was induced by transient overexpression of acute myeloid leukemia 1 in Jurkat T-cells, but not by that of the short form of acute myeloid leukemia 1-MTG8, a chimeric acute myeloid leukemia 1 protein. In 32Dcl3 myeloid cells, stable overexpression of acute myeloid leukemia 1-MTG8 blocked the c-fos gene transcription and cell differentiation, but that of acute myeloid leukemia did not. These data suggest that acute myeloid leukemia 1 and acute myeloid leukemia 1-MTG8 reciprocally regulate the myeloid cell differentiation, possibly by the way of regulating c-fos gene transcription. Copyright (C) 1999 Federation of European Biochemical Societies.

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Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukemia 1

Abstract

Bibliographical note

Keywords

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