Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukemia 1

Eun Sook Hwang, Jeong Ho Hong, Suk Chul Bae, Yoshiaki Ito, Seung Ki Lee

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Both acute myeloid leukemia 1 and c-Fos are regulatory factors of hematopoietic cell differentiation. We identified that the c-fos promoter contains an acute myeloid leukemia 1 binding site at nucleotide positions -6-+14. c-fos promoter activity was induced by transient overexpression of acute myeloid leukemia 1 in Jurkat T-cells, but not by that of the short form of acute myeloid leukemia 1-MTG8, a chimeric acute myeloid leukemia 1 protein. In 32Dcl3 myeloid cells, stable overexpression of acute myeloid leukemia 1-MTG8 blocked the c-fos gene transcription and cell differentiation, but that of acute myeloid leukemia did not. These data suggest that acute myeloid leukemia 1 and acute myeloid leukemia 1-MTG8 reciprocally regulate the myeloid cell differentiation, possibly by the way of regulating c-fos gene transcription. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalFEBS Letters
Volume446
Issue number1
DOIs
StatePublished - 5 Mar 1999

Keywords

  • Acute myeloid leukemia 1
  • Acute myeloid leukemia 1-MTG8
  • c-fos
  • Myeloid cell differentiation
  • Transcription

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