Regulation of autophagy is a novel tumorigenesis-related activity of multifunctional translationally controlled tumor protein

Ji Sun Lee; Eun Hwa Jang; Hyun Ae Woo; Kyunglim Lee

doi:10.3390/cells9010257

Regulation of autophagy is a novel tumorigenesis-related activity of multifunctional translationally controlled tumor protein

Ji Sun Lee, Eun Hwa Jang, Hyun Ae Woo, Kyunglim Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Translationally controlled tumor protein (TCTP) is highly conserved in eukaryotic organisms and plays multiple roles regulating cellular growth and homeostasis. Because of its anti-apoptotic activity and its role in the regulation of cancer metastasis, TCTP has become a promising target for cancer therapy. Moreover, growing evidence points to its clinical role in cancer prognosis. How TCTP regulates cellular growth in cancer has been widely studied, but how it regulates cellular homeostasis has received relatively little attention. This review discusses how TCTP is related to cancer and its potential as a target in cancer therapeutics, including its novel role in the regulation of autophagy. Regulation of autophagy is essential for cell recycling and scavenging cellular materials to sustain cell survival under the metabolic stress that cancer cells undergo during their aggressive proliferation.

Original language	English
Article number	257
Journal	Cells
Volume	9
Issue number	1
DOIs	https://doi.org/10.3390/cells9010257
State	Published - Jan 2020

Bibliographical note

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Autophagy
Cancer
TCTP

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10.3390/cells9010257

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title = "Regulation of autophagy is a novel tumorigenesis-related activity of multifunctional translationally controlled tumor protein",

abstract = "Translationally controlled tumor protein (TCTP) is highly conserved in eukaryotic organisms and plays multiple roles regulating cellular growth and homeostasis. Because of its anti-apoptotic activity and its role in the regulation of cancer metastasis, TCTP has become a promising target for cancer therapy. Moreover, growing evidence points to its clinical role in cancer prognosis. How TCTP regulates cellular growth in cancer has been widely studied, but how it regulates cellular homeostasis has received relatively little attention. This review discusses how TCTP is related to cancer and its potential as a target in cancer therapeutics, including its novel role in the regulation of autophagy. Regulation of autophagy is essential for cell recycling and scavenging cellular materials to sustain cell survival under the metabolic stress that cancer cells undergo during their aggressive proliferation.",

keywords = "Autophagy, Cancer, TCTP",

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year = "2020",

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AU - Lee, Ji Sun

AU - Jang, Eun Hwa

AU - Woo, Hyun Ae

AU - Lee, Kyunglim

PY - 2020/1

Y1 - 2020/1

N2 - Translationally controlled tumor protein (TCTP) is highly conserved in eukaryotic organisms and plays multiple roles regulating cellular growth and homeostasis. Because of its anti-apoptotic activity and its role in the regulation of cancer metastasis, TCTP has become a promising target for cancer therapy. Moreover, growing evidence points to its clinical role in cancer prognosis. How TCTP regulates cellular growth in cancer has been widely studied, but how it regulates cellular homeostasis has received relatively little attention. This review discusses how TCTP is related to cancer and its potential as a target in cancer therapeutics, including its novel role in the regulation of autophagy. Regulation of autophagy is essential for cell recycling and scavenging cellular materials to sustain cell survival under the metabolic stress that cancer cells undergo during their aggressive proliferation.

AB - Translationally controlled tumor protein (TCTP) is highly conserved in eukaryotic organisms and plays multiple roles regulating cellular growth and homeostasis. Because of its anti-apoptotic activity and its role in the regulation of cancer metastasis, TCTP has become a promising target for cancer therapy. Moreover, growing evidence points to its clinical role in cancer prognosis. How TCTP regulates cellular growth in cancer has been widely studied, but how it regulates cellular homeostasis has received relatively little attention. This review discusses how TCTP is related to cancer and its potential as a target in cancer therapeutics, including its novel role in the regulation of autophagy. Regulation of autophagy is essential for cell recycling and scavenging cellular materials to sustain cell survival under the metabolic stress that cancer cells undergo during their aggressive proliferation.

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KW - Cancer

KW - TCTP

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DO - 10.3390/cells9010257

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SN - 2073-4409

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JO - Cells

JF - Cells

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ER -

Regulation of autophagy is a novel tumorigenesis-related activity of multifunctional translationally controlled tumor protein

Abstract

Bibliographical note

Keywords

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