Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer

Soo Jin Lee; Won Woo Lee; Hai Jeon Yoon; Ho Young Lee; Kyoung Ho Lee; Young Hoon Kim; Do Joong Park; Hyung Ho Kim; Young So; Sang Eun Kim

doi:10.1016/j.ejrad.2013.01.014

Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer

Soo Jin Lee
, Won Woo Lee
, Hai Jeon Yoon
, Ho Young Lee
, Kyoung Ho Lee
, Young Hoon Kim
, Do Joong Park
, Hyung Ho Kim
, Young So
, Sang Eun Kim

Department of Nuclear Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Objective: We aimed to improve diagnostic accuracy of ¹⁸F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50% = 24/48) was significantly improved by regional PET/CT (75% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3% = 285/287) was not compromised by regional PET/CT (98.3% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.

Original language	English
Pages (from-to)	935-942
Number of pages	8
Journal	European Journal of Radiology
Volume	82
Issue number	6
DOIs	https://doi.org/10.1016/j.ejrad.2013.01.014
State	Published - Jun 2013

Bibliographical note

Funding Information:
This study was supported in part by a grant of the Korea Healthcare Technology R&D Project , Ministry of Health and Welfare ( A111627 ), and by grants from the National Research Foundation (NRF) , Ministry of Education, Science and Technology (MEST), ( 2012M2B2A9A02029612 and Basic Science Research Program 2012R1A1A2001060 ), Republic of Korea.

Keywords

FDG
Gastric cancer
PET/CT
Staging

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10.1016/j.ejrad.2013.01.014

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@article{61ca425815574c788f42273c63c8d568,

title = "Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer",

abstract = "Objective: We aimed to improve diagnostic accuracy of 18F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50\% = 24/48) was significantly improved by regional PET/CT (75\% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6\% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1\% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3\% = 285/287) was not compromised by regional PET/CT (98.3\% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.",

keywords = "FDG, Gastric cancer, PET/CT, Staging",

author = "Lee, \{Soo Jin\} and Lee, \{Won Woo\} and Yoon, \{Hai Jeon\} and Lee, \{Ho Young\} and Lee, \{Kyoung Ho\} and Kim, \{Young Hoon\} and Park, \{Do Joong\} and Kim, \{Hyung Ho\} and Young So and Kim, \{Sang Eun\}",

note = "Funding Information: This study was supported in part by a grant of the Korea Healthcare Technology R\&D Project , Ministry of Health and Welfare ( A111627 ), and by grants from the National Research Foundation (NRF) , Ministry of Education, Science and Technology (MEST), ( 2012M2B2A9A02029612 and Basic Science Research Program 2012R1A1A2001060 ), Republic of Korea.",

year = "2013",

month = jun,

doi = "10.1016/j.ejrad.2013.01.014",

language = "English",

volume = "82",

pages = "935--942",

journal = "European Journal of Radiology",

issn = "0720-048X",

publisher = "Elsevier Ireland Ltd",

number = "6",

}

TY - JOUR

T1 - Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer

AU - Lee, Soo Jin

AU - Lee, Won Woo

AU - Yoon, Hai Jeon

AU - Lee, Ho Young

AU - Lee, Kyoung Ho

AU - Kim, Young Hoon

AU - Park, Do Joong

AU - Kim, Hyung Ho

AU - So, Young

AU - Kim, Sang Eun

N1 - Funding Information: This study was supported in part by a grant of the Korea Healthcare Technology R&D Project , Ministry of Health and Welfare ( A111627 ), and by grants from the National Research Foundation (NRF) , Ministry of Education, Science and Technology (MEST), ( 2012M2B2A9A02029612 and Basic Science Research Program 2012R1A1A2001060 ), Republic of Korea.

PY - 2013/6

Y1 - 2013/6

N2 - Objective: We aimed to improve diagnostic accuracy of 18F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50% = 24/48) was significantly improved by regional PET/CT (75% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3% = 285/287) was not compromised by regional PET/CT (98.3% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.

AB - Objective: We aimed to improve diagnostic accuracy of 18F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50% = 24/48) was significantly improved by regional PET/CT (75% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3% = 285/287) was not compromised by regional PET/CT (98.3% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.

KW - FDG

KW - Gastric cancer

KW - PET/CT

KW - Staging

UR - https://www.scopus.com/pages/publications/84876915820

U2 - 10.1016/j.ejrad.2013.01.014

DO - 10.1016/j.ejrad.2013.01.014

M3 - Article

C2 - 23410909

AN - SCOPUS:84876915820

SN - 0720-048X

VL - 82

SP - 935

EP - 942

JO - European Journal of Radiology

JF - European Journal of Radiology

IS - 6

ER -

Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer

Abstract

Bibliographical note

Keywords

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