Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer

Soo Jin Lee; Won Woo Lee; Hai Jeon Yoon; Ho Young Lee; Kyoung Ho Lee; Young Hoon Kim; Do Joong Park; Hyung Ho Kim; Young So; Sang Eun Kim

doi:10.1016/j.ejrad.2013.01.014

Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer

Soo Jin Lee, Won Woo Lee, Hai Jeon Yoon, Ho Young Lee, Kyoung Ho Lee, Young Hoon Kim, Do Joong Park, Hyung Ho Kim, Young So, Sang Eun Kim

Department of Nuclear Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Objective: We aimed to improve diagnostic accuracy of ¹⁸F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50% = 24/48) was significantly improved by regional PET/CT (75% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3% = 285/287) was not compromised by regional PET/CT (98.3% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.

Original language	English
Pages (from-to)	935-942
Number of pages	8
Journal	European Journal of Radiology
Volume	82
Issue number	6
DOIs	https://doi.org/10.1016/j.ejrad.2013.01.014
State	Published - Jun 2013

Bibliographical note

Funding Information:
This study was supported in part by a grant of the Korea Healthcare Technology R&D Project , Ministry of Health and Welfare ( A111627 ), and by grants from the National Research Foundation (NRF) , Ministry of Education, Science and Technology (MEST), ( 2012M2B2A9A02029612 and Basic Science Research Program 2012R1A1A2001060 ), Republic of Korea.

Keywords

FDG
Gastric cancer
PET/CT
Staging

Access to Document

10.1016/j.ejrad.2013.01.014

Cite this

@article{61ca425815574c788f42273c63c8d568,

title = "Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer",

abstract = "Objective: We aimed to improve diagnostic accuracy of 18F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50% = 24/48) was significantly improved by regional PET/CT (75% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3% = 285/287) was not compromised by regional PET/CT (98.3% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.",

keywords = "FDG, Gastric cancer, PET/CT, Staging",

author = "Lee, {Soo Jin} and Lee, {Won Woo} and Yoon, {Hai Jeon} and Lee, {Ho Young} and Lee, {Kyoung Ho} and Kim, {Young Hoon} and Park, {Do Joong} and Kim, {Hyung Ho} and Young So and Kim, {Sang Eun}",

note = "Funding Information: This study was supported in part by a grant of the Korea Healthcare Technology R&D Project , Ministry of Health and Welfare ( A111627 ), and by grants from the National Research Foundation (NRF) , Ministry of Education, Science and Technology (MEST), ( 2012M2B2A9A02029612 and Basic Science Research Program 2012R1A1A2001060 ), Republic of Korea.",

year = "2013",

month = jun,

doi = "10.1016/j.ejrad.2013.01.014",

language = "English",

volume = "82",

pages = "935--942",

journal = "European Journal of Radiology",

issn = "0720-048X",

publisher = "Elsevier Ireland Ltd",

number = "6",

}

TY - JOUR

T1 - Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer

AU - Lee, Soo Jin

AU - Lee, Won Woo

AU - Yoon, Hai Jeon

AU - Lee, Ho Young

AU - Lee, Kyoung Ho

AU - Kim, Young Hoon

AU - Park, Do Joong

AU - Kim, Hyung Ho

AU - So, Young

AU - Kim, Sang Eun

N1 - Funding Information: This study was supported in part by a grant of the Korea Healthcare Technology R&D Project , Ministry of Health and Welfare ( A111627 ), and by grants from the National Research Foundation (NRF) , Ministry of Education, Science and Technology (MEST), ( 2012M2B2A9A02029612 and Basic Science Research Program 2012R1A1A2001060 ), Republic of Korea.

PY - 2013/6

Y1 - 2013/6

N2 - Objective: We aimed to improve diagnostic accuracy of 18F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50% = 24/48) was significantly improved by regional PET/CT (75% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3% = 285/287) was not compromised by regional PET/CT (98.3% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.

AB - Objective: We aimed to improve diagnostic accuracy of 18F- fluoro-2-deoxyglucose (FDG) PET/CT for gastric cancer with water gastric inflation. Materials and methods: 44 gastric cancer patients (M:F = 30:14, age ± std = 62.1 ± 14.5y) were enrolled before surgery. Fifty minutes after injection of FDG (0.14 mCi/kg body weight), whole body PET/CT was performed first and then regional PET/CT over gastric area was obtained 80 min post FDG injection after water gastric inflation. Diagnostic accuracies for loco-regional lesions were compared between whole body and regional PET/CT. Results: 48 primary tumors (23 EGC and 25 AGC) and 348 LN stations (61 metastatic and 287 benign) in 44 patients were investigated. Primary tumor sensitivity of whole body PET/CT (50% = 24/48) was significantly improved by regional PET/CT (75% = 36/48, p < 0.005). Sensitivity of whole body PET/CT (24.6% = 15/61) for LN metastasis was also significantly improved by regional PET/CT (36.1% = 22/61, p < 0.01), whereas specificity of whole body PET/CT (99.3% = 285/287) was not compromised by regional PET/CT (98.3% = 282/287, p > 0.05). Higher primary tumor FDG uptake in regional PET/CT indicated shorter progress-free survival (p = 0.0003). Conclusion: Diagnostic accuracy of whole body PET/CT for loco-regional disease of gastric cancer could be significantly improved by regional PET/CT after water gastric inflation and prognosis could be effectively predicted by primary tumor FDG uptake in regional PET/CT.

KW - FDG

KW - Gastric cancer

KW - PET/CT

KW - Staging

UR - http://www.scopus.com/inward/record.url?scp=84876915820&partnerID=8YFLogxK

U2 - 10.1016/j.ejrad.2013.01.014

DO - 10.1016/j.ejrad.2013.01.014

M3 - Article

C2 - 23410909

AN - SCOPUS:84876915820

SN - 0720-048X

VL - 82

SP - 935

EP - 942

JO - European Journal of Radiology

JF - European Journal of Radiology

IS - 6

ER -

Regional PET/CT after water gastric inflation for evaluating loco-regional disease of gastric cancer

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this