Regional atrophy of the corpus callosum in subjects with Alzheimer's disease and multi-infarct dementia

In Kyoon Lyoo; Andrew Satlin; Chang K. Lee; Perry F. Renshaw

doi:10.1016/S0925-4927(97)00009-7

Regional atrophy of the corpus callosum in subjects with Alzheimer's disease and multi-infarct dementia

In Kyoon Lyoo, Andrew Satlin, Chang K. Lee, Perry F. Renshaw

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

Regional areas of the corpus callosum (CC) were evaluated in subjects with dementia. The area of the CC and seven distinct subdivisions were measured in subjects with Alzheimer's disease (AD) (n=162), multi-infarct dementia (MID) (n = 28), and in a healthy comparison group (n = 36). There were significant differences in the regional areas of the CC for both the AD and MID patients relative to values for the comparison subjects. When mildly demented (MMSE ≤ 21), subjects with AD had significantly smaller posterior midbody, isthmus, and splenium and subjects with MID had significantly smaller genu relative to comparison subjects. This study reports different patterns of regional CC area loss in subjects with AD and MID.

Original language	English
Pages (from-to)	63-72
Number of pages	10
Journal	Psychiatry Research - Neuroimaging
Volume	74
Issue number	2
DOIs	https://doi.org/10.1016/S0925-4927(97)00009-7
State	Published - 16 May 1997

Keywords

Alzheimer's disease
Brain magnetic resonance
Corpus callosum
Multi- infarct dementia

UN SDGs

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10.1016/S0925-4927(97)00009-7

Cite this

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abstract = "Regional areas of the corpus callosum (CC) were evaluated in subjects with dementia. The area of the CC and seven distinct subdivisions were measured in subjects with Alzheimer's disease (AD) (n=162), multi-infarct dementia (MID) (n = 28), and in a healthy comparison group (n = 36). There were significant differences in the regional areas of the CC for both the AD and MID patients relative to values for the comparison subjects. When mildly demented (MMSE ≤ 21), subjects with AD had significantly smaller posterior midbody, isthmus, and splenium and subjects with MID had significantly smaller genu relative to comparison subjects. This study reports different patterns of regional CC area loss in subjects with AD and MID.",

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AU - Satlin, Andrew

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Regional atrophy of the corpus callosum in subjects with Alzheimer's disease and multi-infarct dementia

Abstract

Keywords

UN SDGs

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