Reductive DNA cleavage induced by UVA photoirradiation of NADH without oxygen

Makiko Tanaka; Kei Ohkubo; Shunichi Fukuzumi

doi:10.1021/ja065073i

Reductive DNA cleavage induced by UVA photoirradiation of NADH without oxygen

Makiko Tanaka, Kei Ohkubo, Shunichi Fukuzumi

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

UVA irradiation of dihydronicotinamide coenzyme (NADH), which plays a key role in a number of biological redox processes, results in effective DNA cleavage without oxygen via photoionization of NADH and the subsequent reaction of hydrated electron with DNA as well as photoinduced electron transfer from NADH to DNA.

Original language	English
Pages (from-to)	12372-12373
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	38
DOIs	https://doi.org/10.1021/ja065073i
State	Published - 27 Sep 2006

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@article{52b70df4c51a4b3d9e209639edf61222,

title = "Reductive DNA cleavage induced by UVA photoirradiation of NADH without oxygen",

abstract = "UVA irradiation of dihydronicotinamide coenzyme (NADH), which plays a key role in a number of biological redox processes, results in effective DNA cleavage without oxygen via photoionization of NADH and the subsequent reaction of hydrated electron with DNA as well as photoinduced electron transfer from NADH to DNA.",

author = "Makiko Tanaka and Kei Ohkubo and Shunichi Fukuzumi",

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AU - Tanaka, Makiko

AU - Ohkubo, Kei

AU - Fukuzumi, Shunichi

PY - 2006/9/27

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AB - UVA irradiation of dihydronicotinamide coenzyme (NADH), which plays a key role in a number of biological redox processes, results in effective DNA cleavage without oxygen via photoionization of NADH and the subsequent reaction of hydrated electron with DNA as well as photoinduced electron transfer from NADH to DNA.

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U2 - 10.1021/ja065073i

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EP - 12373

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 38

ER -

Reductive DNA cleavage induced by UVA photoirradiation of NADH without oxygen

Abstract

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