Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy

Zulal Özdemir, Mengyao Yang, Gyoungmi Kim, Uladzimir Bildziukevich, David Šaman, Xingshu Li, Juyoung Yoon, Zdeněk Wimmer

Research output: Contribution to journalArticlepeer-review

Abstract

The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (1O2) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT).

Original languageEnglish
Article number109307
JournalDyes and Pigments
Volume190
DOIs
StatePublished - Jun 2021

Keywords

  • Photodynamic therapy
  • Redox-responsive
  • ROS
  • Self-assembled nanoparticles
  • Tumour targeting

Fingerprint

Dive into the research topics of 'Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy'. Together they form a unique fingerprint.

Cite this