Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy

Zulal Özdemir; Mengyao Yang; Gyoungmi Kim; Uladzimir Bildziukevich; David Šaman; Xingshu Li; Juyoung Yoon; Zdeněk Wimmer

doi:10.1016/j.dyepig.2021.109307

Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy

Zulal Özdemir, Mengyao Yang, Gyoungmi Kim, Uladzimir Bildziukevich, David Šaman, Xingshu Li, Juyoung Yoon, Zdeněk Wimmer

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (¹O₂) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT).

Original language	English
Article number	109307
Journal	Dyes and Pigments
Volume	190
DOIs	https://doi.org/10.1016/j.dyepig.2021.109307
State	Published - Jun 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

Photodynamic therapy
ROS
Redox-responsive
Self-assembled nanoparticles
Tumour targeting

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title = "Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy",

abstract = "The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (1O2) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT).",

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doi = "10.1016/j.dyepig.2021.109307",

language = "English",

volume = "190",

journal = "Dyes and Pigments",

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T1 - Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy

AU - Özdemir, Zulal

AU - Yang, Mengyao

AU - Kim, Gyoungmi

AU - Bildziukevich, Uladzimir

AU - Šaman, David

AU - Li, Xingshu

AU - Yoon, Juyoung

AU - Wimmer, Zdeněk

PY - 2021/6

Y1 - 2021/6

N2 - The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (1O2) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT).

AB - The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (1O2) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT).

KW - Photodynamic therapy

KW - ROS

KW - Redox-responsive

KW - Self-assembled nanoparticles

KW - Tumour targeting

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DO - 10.1016/j.dyepig.2021.109307

M3 - Article

AN - SCOPUS:85103374821

SN - 0143-7208

VL - 190

JO - Dyes and Pigments

JF - Dyes and Pigments

M1 - 109307

ER -

Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy

Abstract

Bibliographical note

Keywords

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