Recovery from Posttraumatic Stress Requires Dynamic and Sequential Shifts in Amygdalar Connectivities

Sujung Yoon, Jieun E. Kim, Jaeuk Hwang, Ilhyang Kang, Saerom Jeon, Jooyeon J. Im, Bori R. Kim, Sunho Lee, Geon Ha Kim, Hyewhon Rhim, Soo Mee Lim, In Kyoon Lyoo

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The neural mechanisms underlying the development and maintenance of posttraumatic stress disorder (PTSD) have long been studied. However, little is known about the neural correlates of the recovery process from PTSD. A 5-year longitudinal study was conducted to investigate the trajectory of structural connectivities of the amygdala in disaster survivors with PTSD. Thirty disaster survivors, who were diagnosed with PTSD, and 29 healthy individuals, who were not exposed to trauma, underwent three waves of assessments including neuroimaging scanning over a 5-year period from the time of the disaster at approximately 1.3-year intervals. All disaster survivors showed significant improvements in PTSD symptoms over time. Using diffusion tensor imaging analysis, a 5-year trajectory of amygdalar structural connectivities with key brain regions was assessed. The amygdala-insula connection was initially strengthened and then normalized during recovery, while the amygdala-prefrontal cortex (PFC) connection was at first unaffected, then strengthened, and eventually normalized. The lower tract strength of the amygdala-thalamus connection normalized during recovery, while that of amygdala-hippocampus connection remained low. The greater amygdala-PFC connectivity was associated with less PTSD symptom severity. The present longitudinal study revealed that recovery from PTSD parallels dynamic and sequential shifts in amygdalar connectivities with multiple brain regions, suggesting the expanded view of fear circuitry including the insula and thalamus, beyond the traditional model which primarily involves the amygdala, PFC, and hippocampus.

Original languageEnglish
Pages (from-to)454-461
Number of pages8
JournalNeuropsychopharmacology
Volume42
Issue number2
DOIs
StatePublished - 1 Jan 2017

Bibliographical note

Funding Information:
This project was supported by 2015M3C7A1028373, 2015M3C7A1028376, and 2013R1A2A2A01010309 grants from the National Research Foundation of Korea.

Publisher Copyright:
© 2017 American College of Neuropsychopharmacology.

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