@article{c8a23fe347d340ec96766ecd9ccb54c0,
title = "Recombinant measles virus encoding the spike protein of SARS-CoV-2 efficiently induces Th1 responses and neutralizing antibodies that block SARS-CoV-2 variants",
abstract = "Owing to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, the development of effective and safe vaccines has become a priority. The measles virus (MeV) vaccine is an attractive vaccine platform as it has been administered to children for more than 40 years in over 100 countries. In this study, we developed a recombinant MeV expressing the full-length SARS-CoV-2 spike protein (rMeV-S) and tested its efficacy using mouse and hamster models. In hCD46Tg mice, two-dose rMeV-S vaccination induced higher Th1 secretion and humoral responses than one-dose vaccination. Interestingly, neutralizing antibodies induced by one-dose and two-dose rMeV-S immunization effectively blocked the entry of the α, β, γ, and δ variants of SARS-CoV-2. Furthermore, two-dose rMeV-S immunization provided complete protection against SARS-CoV-2 in the hamster model. These results suggest the potential of rMeV-S as a vaccine candidate for targeting SARS-CoV-2 and its variants.",
keywords = "Measles virus vector, Neutralizing antibody, SARS-CoV-2",
author = "Kwak, {Hye Won} and Park, {Hyo Jung} and Jung, {Seo Yeon} and Oh, {Eun Young} and Park, {Sang In} and Yeonhwa Kim and Park, {Hyeong Jun} and Sohyun Park and Kim, {You Jin} and Ko, {Hae Li} and Lee, {Jung Ah} and Hyeran Won and Hwang, {Yun Ho} and Kim, {Seo Yeon} and Kim, {Se Eun} and Bae, {Seoung Eun} and Minhyuk Yoon and Kim, {Jae Ouk} and Manki Song and Lee, {Su Jeen} and Seo, {Ki Weon} and Kunse Lee and Dokeun Kim and Hun Kim and Lee, {Sang Myeong} and Hong, {So Hee} and Nam, {Jae Hwan}",
note = "Funding Information: This work was supported by the Research Investment for Global Health Technology Fund [RIGHT Fund]; SK Bioscience [grant numbers M-2020-D0731-0001, M-2020-D0732-0003]; the Korea Health Industry Development Institute (KHIDI) funded by the Ministry for Health and Welfare, Republic of Korea [grant number KHIDIHV21C0020020021]; the National Research Foundation (NRF) funded by the Ministry of Science and ICT, Republic of Korea [grant number 2021M3E5E3080558]; and the Brain Korea 21 Plus Program. Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",
year = "2023",
month = mar,
day = "10",
doi = "10.1016/j.vaccine.2023.02.005",
language = "English",
volume = "41",
pages = "1892--1901",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "11",
}