Recent trends in creatinine assays in Korea: Long-term accuracy-based proficiency testing survey data by the Korean association of external quality assessment service (2011–2019)

Tae Dong Jeong, Eun Jung Cho, Kyunghoon Lee, Woochang Lee, Yeo Min Yun, Sail Chun, Junghan Song, Won Ki Min

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Accurate serum creatinine (Cr) concentration measurement is essential for evaluating kidney function. In 2011, the Korean Association of External Quality Assessment Service (KEQAS) launched an accuracy-based Cr proficiency testing (ABCr PT) survey. We analyzed long-term data of the KEQAS ABCr PT survey collected between 2011 and 2019 to assess recent trends in Cr assays in Korea. Methods: The ABCr PT survey including three commutable fresh-frozen serum samples was performed twice a year. The target Cr concentration was assigned using isotope-dilution mass spectrometry. We analyzed data obtained from the participating laboratories, calculated the yearly bias, and evaluated bias trends for the major reagents and instruments. Outliers were excluded from all analysis. Results: The mean percentage bias based on the total data of all participating laboratories was 10.8% in the 2011-A survey and 0.2% in 2019-B survey. Bias for the major reagents and instruments differed depending on the manufacturer. Enzymatic assays generally showed desirable bias ranging from –3.9% to 3.2% at all Cr concentrations and lower interlaboratory variability than non-enzymatic assays (enzymatic vs. non-enzymatic, 3.3%–7.2% vs. 6.3%–9.1%). Conclusions: Although the mean percentage bias of Cr assays tends to decrease over time, it is necessary to continuously strive to improve Cr assay accuracy, especially at low concentrations.

Original languageEnglish
Pages (from-to)372-379
Number of pages8
JournalAnnals of Laboratory Medicine
Volume41
Issue number4
DOIs
StatePublished - 1 Jul 2021

Keywords

  • Accuracy
  • Bias
  • Creatinine
  • Proficiency testing
  • Survey

Fingerprint

Dive into the research topics of 'Recent trends in creatinine assays in Korea: Long-term accuracy-based proficiency testing survey data by the Korean association of external quality assessment service (2011–2019)'. Together they form a unique fingerprint.

Cite this