Recent progress on the development of glutathione (GSH) selective fluorescent and colorimetric probes

Songyi Lee; Jun Li; Xin Zhou; Jun Yin; Juyoung Yoon

doi:10.1016/j.ccr.2018.03.021

Recent progress on the development of glutathione (GSH) selective fluorescent and colorimetric probes

Songyi Lee, Jun Li, Xin Zhou, Jun Yin, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Review article › peer-review

237 Scopus citations

Abstract

Glutathione (GSH) plays a key role in many cellular functions. Abnormal levels of GSH is considered to be sign of many diseases. As a result, various fluorescent imaging probes and/or chemosensors for GSH have been developed. Compared to other analytical methods, fluorescence has unique merits, such as excellent detection limits and sensitivity for use in imaging cells, tissues and small animals. However, colorimetric probes undergo distinct color changes, which in most cases can be detected by using the naked eye. This review of studies aimed at the development of GSH probes is presented in a format that is organized by structural features and chemical reactions of the probes. The topics include probes that are based on nanoparticles or nanocomposites, metal ion displacement and coordination and chemical reactions. The reaction based probes are further classified into probes that undergo cleavage of sulphonamide, sulfonate ester and related functional groups, Se–N bond cleavage, aryl substitution reactions, disulfide bond cleavage followed by cyclization, Michael additions, and other processes.

Original language	English
Pages (from-to)	29-68
Number of pages	40
Journal	Coordination Chemistry Reviews
Volume	366
DOIs	https://doi.org/10.1016/j.ccr.2018.03.021
State	Published - 1 Jul 2018

Bibliographical note

Funding Information:
The authors studies included in this review were supported by the National Creative Research Initiative program (grant no. 2012R1A3A2048814) for J.Y. (Juyoung Yoon) and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2017R1A6A3A04004954) for S.L. And Xin Zhou acknowledge the Natural Science Foundation of China (NSFC. 21662037, 21762045) for supporting this work. J.Y. (Jun Yin) acknowledges financial support from National Natural Science Foundation of China (21676113).

Funding Information:
The authors studies included in this review were supported by the National Creative Research Initiative program (grant no. 2012R1A3A2048814) for J.Y. (Juyoung Yoon) and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2017R1A6A3A04004954 ) for S.L. And Xin Zhou acknowledge the Natural Science Foundation of China (NSFC. 21662037 , 21762045 ) for supporting this work. J.Y. (Jun Yin) acknowledges financial support from National Natural Science Foundation of China ( 21676113 ).

Publisher Copyright:
© 2018 Elsevier B.V.

Keywords

Bioimaging
Biothiol probes
Colorimetric chemosensors
Fluorescence probes
GSH probes
Glutathione probe

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10.1016/j.ccr.2018.03.021

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title = "Recent progress on the development of glutathione (GSH) selective fluorescent and colorimetric probes",

abstract = "Glutathione (GSH) plays a key role in many cellular functions. Abnormal levels of GSH is considered to be sign of many diseases. As a result, various fluorescent imaging probes and/or chemosensors for GSH have been developed. Compared to other analytical methods, fluorescence has unique merits, such as excellent detection limits and sensitivity for use in imaging cells, tissues and small animals. However, colorimetric probes undergo distinct color changes, which in most cases can be detected by using the naked eye. This review of studies aimed at the development of GSH probes is presented in a format that is organized by structural features and chemical reactions of the probes. The topics include probes that are based on nanoparticles or nanocomposites, metal ion displacement and coordination and chemical reactions. The reaction based probes are further classified into probes that undergo cleavage of sulphonamide, sulfonate ester and related functional groups, Se–N bond cleavage, aryl substitution reactions, disulfide bond cleavage followed by cyclization, Michael additions, and other processes.",

keywords = "Bioimaging, Biothiol probes, Colorimetric chemosensors, Fluorescence probes, GSH probes, Glutathione probe",

author = "Songyi Lee and Jun Li and Xin Zhou and Jun Yin and Juyoung Yoon",

note = "Funding Information: The authors studies included in this review were supported by the National Creative Research Initiative program (grant no. 2012R1A3A2048814) for J.Y. (Juyoung Yoon) and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2017R1A6A3A04004954) for S.L. And Xin Zhou acknowledge the Natural Science Foundation of China (NSFC. 21662037, 21762045) for supporting this work. J.Y. (Jun Yin) acknowledges financial support from National Natural Science Foundation of China (21676113). Funding Information: The authors studies included in this review were supported by the National Creative Research Initiative program (grant no. 2012R1A3A2048814) for J.Y. (Juyoung Yoon) and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2017R1A6A3A04004954 ) for S.L. And Xin Zhou acknowledge the Natural Science Foundation of China (NSFC. 21662037 , 21762045 ) for supporting this work. J.Y. (Jun Yin) acknowledges financial support from National Natural Science Foundation of China ( 21676113 ). Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",

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AU - Zhou, Xin

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N1 - Funding Information: The authors studies included in this review were supported by the National Creative Research Initiative program (grant no. 2012R1A3A2048814) for J.Y. (Juyoung Yoon) and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2017R1A6A3A04004954) for S.L. And Xin Zhou acknowledge the Natural Science Foundation of China (NSFC. 21662037, 21762045) for supporting this work. J.Y. (Jun Yin) acknowledges financial support from National Natural Science Foundation of China (21676113). Funding Information: The authors studies included in this review were supported by the National Creative Research Initiative program (grant no. 2012R1A3A2048814) for J.Y. (Juyoung Yoon) and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (No. 2017R1A6A3A04004954 ) for S.L. And Xin Zhou acknowledge the Natural Science Foundation of China (NSFC. 21662037 , 21762045 ) for supporting this work. J.Y. (Jun Yin) acknowledges financial support from National Natural Science Foundation of China ( 21676113 ). Publisher Copyright: © 2018 Elsevier B.V.

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N2 - Glutathione (GSH) plays a key role in many cellular functions. Abnormal levels of GSH is considered to be sign of many diseases. As a result, various fluorescent imaging probes and/or chemosensors for GSH have been developed. Compared to other analytical methods, fluorescence has unique merits, such as excellent detection limits and sensitivity for use in imaging cells, tissues and small animals. However, colorimetric probes undergo distinct color changes, which in most cases can be detected by using the naked eye. This review of studies aimed at the development of GSH probes is presented in a format that is organized by structural features and chemical reactions of the probes. The topics include probes that are based on nanoparticles or nanocomposites, metal ion displacement and coordination and chemical reactions. The reaction based probes are further classified into probes that undergo cleavage of sulphonamide, sulfonate ester and related functional groups, Se–N bond cleavage, aryl substitution reactions, disulfide bond cleavage followed by cyclization, Michael additions, and other processes.

AB - Glutathione (GSH) plays a key role in many cellular functions. Abnormal levels of GSH is considered to be sign of many diseases. As a result, various fluorescent imaging probes and/or chemosensors for GSH have been developed. Compared to other analytical methods, fluorescence has unique merits, such as excellent detection limits and sensitivity for use in imaging cells, tissues and small animals. However, colorimetric probes undergo distinct color changes, which in most cases can be detected by using the naked eye. This review of studies aimed at the development of GSH probes is presented in a format that is organized by structural features and chemical reactions of the probes. The topics include probes that are based on nanoparticles or nanocomposites, metal ion displacement and coordination and chemical reactions. The reaction based probes are further classified into probes that undergo cleavage of sulphonamide, sulfonate ester and related functional groups, Se–N bond cleavage, aryl substitution reactions, disulfide bond cleavage followed by cyclization, Michael additions, and other processes.

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JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

ER -

Recent progress on the development of glutathione (GSH) selective fluorescent and colorimetric probes

Abstract

Bibliographical note

Keywords

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