Recent progress on small molecule-based fluorescent imaging probes for hypochlorous acid (HOCl)/hypochlorite (OCl−)

Nahyun Kwon; Yahui Chen; Xiaoqiang Chen; Myung Hwa Kim; Juyoung Yoon

doi:10.1016/j.dyepig.2022.110132

Recent progress on small molecule-based fluorescent imaging probes for hypochlorous acid (HOCl)/hypochlorite (OCl⁻)

Nahyun Kwon, Yahui Chen, Xiaoqiang Chen, Myung Hwa Kim, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Reactive oxygen species (ROS) and nitrogen species (RNS) are very important in various pathological and physiological processes. In particular, hypochlorous acid/hypochlorite (HOCl/OCl⁻) is one of the most important reactive oxygen species (ROS), which is endogenously produced from H₂O₂ and Cl⁻ by myeloperoxidase (MPO) catalysis. HOCl is both beneficial and harmful to living species including humans. HOCl can destroy invasive bacteria as an immune defense system while, on the other hand, it can cause many diseases including cancers due to pathogenic oxidative stress injury. Accordingly, fluorescent imaging probes for HOCl have been actively investigated in recent years. In this review, we cover the recent progress from 2019 to 2021 on small molecule-based fluorescent imaging probes for hypochlorous acid (HOCl)/hypochlorite (OCl⁻).

Original language	English
Article number	110132
Journal	Dyes and Pigments
Volume	200
DOIs	https://doi.org/10.1016/j.dyepig.2022.110132
State	Published - Apr 2022

Bibliographical note

Funding Information:
This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF- 2018R1A6A1A03025340 for M. H. K. and 2021R1A6A1A10039823 for J.Y.). The work was also supported financially by the National Natural Science Foundation of China ( 21978131 ) and the State Key Laboratory of Materials- Oriented Chemical Engineering ( KL18-02 ).

Funding Information:
This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A6A1A03025340 for M. H. K. and 2021R1A6A1A10039823 for J.Y.). The work was also supported financially by the National Natural Science Foundation of China (21978131) and the State Key Laboratory of Materials- Oriented Chemical Engineering (KL18-02).

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

Fluorescent imaging probes
Hypochlorous acid/hypochlorite (HOCl/OCl)
Reactive oxygen species (ROS)
Small molecules

Access to Document

10.1016/j.dyepig.2022.110132

Cite this

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title = "Recent progress on small molecule-based fluorescent imaging probes for hypochlorous acid (HOCl)/hypochlorite (OCl−)",

abstract = "Reactive oxygen species (ROS) and nitrogen species (RNS) are very important in various pathological and physiological processes. In particular, hypochlorous acid/hypochlorite (HOCl/OCl−) is one of the most important reactive oxygen species (ROS), which is endogenously produced from H2O2 and Cl− by myeloperoxidase (MPO) catalysis. HOCl is both beneficial and harmful to living species including humans. HOCl can destroy invasive bacteria as an immune defense system while, on the other hand, it can cause many diseases including cancers due to pathogenic oxidative stress injury. Accordingly, fluorescent imaging probes for HOCl have been actively investigated in recent years. In this review, we cover the recent progress from 2019 to 2021 on small molecule-based fluorescent imaging probes for hypochlorous acid (HOCl)/hypochlorite (OCl−).",

keywords = "Fluorescent imaging probes, Hypochlorous acid/hypochlorite (HOCl/OCl), Reactive oxygen species (ROS), Small molecules",

author = "Nahyun Kwon and Yahui Chen and Xiaoqiang Chen and Kim, {Myung Hwa} and Juyoung Yoon",

note = "Funding Information: This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF- 2018R1A6A1A03025340 for M. H. K. and 2021R1A6A1A10039823 for J.Y.). The work was also supported financially by the National Natural Science Foundation of China ( 21978131 ) and the State Key Laboratory of Materials- Oriented Chemical Engineering ( KL18-02 ). Funding Information: This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A6A1A03025340 for M. H. K. and 2021R1A6A1A10039823 for J.Y.). The work was also supported financially by the National Natural Science Foundation of China (21978131) and the State Key Laboratory of Materials- Oriented Chemical Engineering (KL18-02). Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

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N2 - Reactive oxygen species (ROS) and nitrogen species (RNS) are very important in various pathological and physiological processes. In particular, hypochlorous acid/hypochlorite (HOCl/OCl−) is one of the most important reactive oxygen species (ROS), which is endogenously produced from H2O2 and Cl− by myeloperoxidase (MPO) catalysis. HOCl is both beneficial and harmful to living species including humans. HOCl can destroy invasive bacteria as an immune defense system while, on the other hand, it can cause many diseases including cancers due to pathogenic oxidative stress injury. Accordingly, fluorescent imaging probes for HOCl have been actively investigated in recent years. In this review, we cover the recent progress from 2019 to 2021 on small molecule-based fluorescent imaging probes for hypochlorous acid (HOCl)/hypochlorite (OCl−).

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