Recent progress of TP/NIR fluorescent probes for metal ions

Yahui Chen, Shiyue Zheng, Myung Hwa Kim, Xiaoqiang Chen, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Metal ions are of significance in various pathological and physiological processes. As such, it is crucial to monitor their levels in organisms. Two-photon (TP) and near-infrared (NIR) fluorescence imaging has been utilized to monitor metal ions because of minimal background interference, deeper tissue depth penetration, lower tissue self-absorption, and reduced photodamage. In this review, we briefly summarize recent progress from 2020 to 2022 of TP/NIR organic fluorescent probes and inorganic sensors in the detection of metal ions. Additionally, we present an outlook for the development of TP/NIR probes for bio-imaging, diagnosis of diseases, imaging-guided therapy, and activatable phototherapy.

Original languageEnglish
Article number102321
JournalCurrent Opinion in Chemical Biology
StatePublished - Aug 2023

Bibliographical note

Funding Information:
This work was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (NRF-2018R1A6A1A03025340) and t he Korea Government (MSIT) (2021R1A6A1A10039823 for J.Y.) . The work was also supported financially by the National Natural Science Foundation of China ( 22278224 and 21978131 ).

Publisher Copyright:
© 2023 Elsevier Ltd


  • Fluorescence imaging
  • Fluorescent probes
  • Metal ions
  • Near-infrared
  • Two-photon


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