TY - JOUR
T1 - Recent progress in development of synthetic biology platforms and metabolic engineering of Corynebacterium glutamicum
AU - Woo, Han Min
AU - Park, Jin Byung
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea grant-funded by the Korean Government (Ministry of Science, ICT & Future Planning) (2014, University-Institute Cooperation program) and Creative Allied Program (CAP) of the Korea Research Council of Fundamental Science and Technology (KRCF)/Korea Institute of Science and Technology (KIST) (Project No. 2E24832 ).
PY - 2014/6/20
Y1 - 2014/6/20
N2 - The paradigm of synthetic biology has been evolving, along with relevant engineering, to achieve designed bio-systems. Synthetic biology has reached the point where it is possible to develop microbial strains to produce desired chemicals. Recent advances in this field have promoted metabolic engineering of Corynebacterium glutamicum as an amino-acid producer for use in intelligent microbial-cell factories. Here, we review recent advances that address C. glutamicum as a potential model organism for synthetic biology, and evaluate their industrial applications. Finally, we highlight the perspective of developing C. glutamicum as a step toward advanced microbial-cell factories that could produce valuable chemicals from renewable resources.
AB - The paradigm of synthetic biology has been evolving, along with relevant engineering, to achieve designed bio-systems. Synthetic biology has reached the point where it is possible to develop microbial strains to produce desired chemicals. Recent advances in this field have promoted metabolic engineering of Corynebacterium glutamicum as an amino-acid producer for use in intelligent microbial-cell factories. Here, we review recent advances that address C. glutamicum as a potential model organism for synthetic biology, and evaluate their industrial applications. Finally, we highlight the perspective of developing C. glutamicum as a step toward advanced microbial-cell factories that could produce valuable chemicals from renewable resources.
KW - Corynebacterium glutamicum
KW - Industrial host
KW - Metabolic engineering
KW - Synthetic biology
UR - http://www.scopus.com/inward/record.url?scp=84898998925&partnerID=8YFLogxK
U2 - 10.1016/j.jbiotec.2014.03.003
DO - 10.1016/j.jbiotec.2014.03.003
M3 - Article
C2 - 24632177
AN - SCOPUS:84898998925
SN - 0168-1656
VL - 180
SP - 43
EP - 51
JO - Journal of Biotechnology
JF - Journal of Biotechnology
ER -
