Recent progress in development of synthetic biology platforms and metabolic engineering of Corynebacterium glutamicum

Han Min Woo, Jin Byung Park

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

The paradigm of synthetic biology has been evolving, along with relevant engineering, to achieve designed bio-systems. Synthetic biology has reached the point where it is possible to develop microbial strains to produce desired chemicals. Recent advances in this field have promoted metabolic engineering of Corynebacterium glutamicum as an amino-acid producer for use in intelligent microbial-cell factories. Here, we review recent advances that address C. glutamicum as a potential model organism for synthetic biology, and evaluate their industrial applications. Finally, we highlight the perspective of developing C. glutamicum as a step toward advanced microbial-cell factories that could produce valuable chemicals from renewable resources.

Original languageEnglish
Pages (from-to)43-51
Number of pages9
JournalJournal of Biotechnology
Volume180
DOIs
StatePublished - 20 Jun 2014

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea grant-funded by the Korean Government (Ministry of Science, ICT & Future Planning) (2014, University-Institute Cooperation program) and Creative Allied Program (CAP) of the Korea Research Council of Fundamental Science and Technology (KRCF)/Korea Institute of Science and Technology (KIST) (Project No. 2E24832 ).

Keywords

  • Corynebacterium glutamicum
  • Industrial host
  • Metabolic engineering
  • Synthetic biology

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