Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways

Debra Dorotea, Daisuke Koya, Hunjoo Ha

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Sterol regulatory-element binding proteins (SREBPs) are classical regulators of cellular lipid metabolism in the kidney and other tissues. SREBPs are currently recognized as versatile transcription factors involved in a myriad of cellular processes. Meanwhile, SREBPs have been recognized to mediate lipotoxicity, contributing to the progression of kidney diseases. SREBP1 has been shown to bind to the promoter region of TGFβ, a major pro-fibrotic signaling mechanism in the kidney. Conversely, TGFβ activates SREBP1 transcriptional activity suggesting a positive feedback loop of SREBP1 in TGFβ signaling. Public ChIP-seq data revealed numerous non-lipid transcriptional targets of SREBPs that plausibly play roles in progressive kidney disease and fibrosis. This review provides new insights into SREBP as a mediator of kidney fibrosis via lipid-independent pathways.

Original languageEnglish
Article number265
JournalFrontiers in Pharmacology
Volume11
DOIs
StatePublished - 17 Mar 2020

Keywords

  • SREBP
  • TGFβ
  • kidney fibrosis
  • lipotoxicity
  • renal lipid

Fingerprint

Dive into the research topics of 'Recent Insights Into SREBP as a Direct Mediator of Kidney Fibrosis via Lipid-Independent Pathways'. Together they form a unique fingerprint.

Cite this