Recent chemotherapy reduces the maximum-standardized uptake value of 18f-fluoro-deoxyglucose positron emission tomography in colorectal cancer

Minjong Lee, Tae Sung Yeum, Ji Won Kim, Sohee Oh, Shin Ae Lee, Hong Ran Moon, Young Hoon Choi, Yoo Min Han, Ji Min Choi, Dong Kee Jang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background/Aims: The aim of this study was to evaluate the influence of recent chemotherapy on the patterns of the maximum-standardized uptake value (M-SUV) and sensitivity of 18F-fluoro-deoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in colorectal cancer. Methods: We retrospectively analyzed the FDG-PET/CT of 509 patients who underwent surgery for colorectal cancer. Subgroup analysis was performed according to chemotherapy status; 401 patients were not treated with chemotherapy and 108 patients were treated with chemotherapy within 6 months prior to surgery. Pathologic analysis of the surgical specimen was used as the gold standard. Results: The M-SUV was significantly lower in patients treated with chemotherapy than in those not treated with chemotherapy in pathologically confirmed same stages of disease. The difference in the sensitivity of the M-SUV according to chemotherapy status was greatest using a cutoff M-SUV value of 6.4 (p<0.001). The longest diameter of the primary tumor was the most important factor that correlated with M-SUV of the primary tumor irrespective of the chemotherapy effect (p<0.001). The M-SUV of the primary tumor was not an independent predictor of lymph node metastasis in colorectal cancer. Conclusions: The results indicate that the M-SUV of FDG-PET/CT should be interpreted in the context of concurrent chemotherapy.

Original languageEnglish
Pages (from-to)254-264
Number of pages11
JournalGut and Liver
Volume8
Issue number3
DOIs
StatePublished - May 2014

Keywords

  • Colorectal neoplasms
  • Drug therapy
  • FDG-PET/CT

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